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Titolo:
S-100B and neuron-specific enolase in serum of mild traumatic brain injurypatients - A comparison with healthy controls
Autore:
de Kruijk, JR; Leffers, P; Menheere, PPCA; Meerhoff, S; Twijnstra, A;
Indirizzi:
Univ Hosp Maastricht, Dept Neurol, NL-6229 HX Maastricht, Netherlands UnivHosp Maastricht Maastricht Netherlands NL-6229 HX icht, Netherlands Univ Hosp Maastricht, Dept Clin Chem, Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands em, Maastricht, Netherlands Maastricht Univ, Dept Epidemiol, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands idemiol, Maastricht, Netherlands
Titolo Testata:
ACTA NEUROLOGICA SCANDINAVICA
fascicolo: 3, volume: 103, anno: 2001,
pagine: 175 - 179
SICI:
0001-6314(200103)103:3<175:SANEIS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HEAD-INJURY; MYELIN BASIC-PROTEIN; COMPUTED-TOMOGRAPHY; DAMAGE;
Keywords:
mild traumatic brain injury; neuron-specific enolase; S-100B; vomiting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: de Kruijk, JR Univ Hosp Maastricht, Dept Neurol, P Debeylaan 25, NL-6229 HX Maastricht, Netherlands Univ Hosp Maastricht P Debeylaan 25 Maastricht Netherlands NL-6229 HX
Citazione:
J.R. de Kruijk et al., "S-100B and neuron-specific enolase in serum of mild traumatic brain injurypatients - A comparison with healthy controls", ACT NEUR SC, 103(3), 2001, pp. 175-179

Abstract

Objectives - The aim of the study was to determine whether serum concentrations of neuron-specific enolase (NSE) and S100-B in mild traumatic brain injury (MTBI) patients are higher than in serum of healthy controls. Material and methods - Blood samples from 104 MTBI patients were taken shortly after the trauma for measurement of S-100B and NSE in serum. In 92 healthy persons these markers were also measured. Marker concentrations in serum of patients and controls were compared. In the patient group the relation between serum-marker concentrations and clinical symptoms and signs, that occurred shortly after the traumatic event, were evaluated. Results - Median NSE concentration was only slightly higher in patients (9.8 mug/l; 10 to 90 percentile range 6.9 to 14.3,mug/l) than in controls (9.4 mug/l; 6.3 to 13.3 mug/l). Median S-100B concentration was significantly higher in patients (0.25 mug/l; 0.00 to 0.68 mug/l) than in controls (0.02 mug/l; 0.90 to 0.13 mug/l). An association was found between S-100B concentrations and vomiting inpatients. Conclusions - S-100B is a useful marker for brain damage in MTBIpatients and seems to be associated with the presence of vomiting after the trauma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:50:51