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Titolo:
Evaluation of hepatocellular carcinoma after treatment with transcatheter arterial chemoembolization: comparison of Lipiodol-CT, power Doppler sonography, and dynamic MRI
Autore:
Kubota, K; Hisa, N; Nishikawa, T; Fujiwara, Y; Murata, Y; Itoh, S; Yoshida, D; Yoshida, S;
Indirizzi:
Kochi Med Sch, Dept Radiol, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 Radiol, Nanko Ku, Kochi 7838505, Japan
Titolo Testata:
ABDOMINAL IMAGING
fascicolo: 2, volume: 26, anno: 2001,
pagine: 184 - 190
SICI:
0942-8925(200103/04)26:2<184:EOHCAT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERCUTANEOUS ETHANOL INJECTION; COLOR-DOPPLER; CONTRAST AGENT; PATHOLOGICAL CORRELATION; IODIZED OIL; EMBOLIZATION; US; VASCULATURE; EFFICACY;
Keywords:
hepatocellular carcinoma; liver neoplasms, MR; liver neoplasms, US; liver neoplasms, CT; liver neoplasms, interventional procedure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kubota, K Kochi Med Sch, Dept Radiol, Nanko Ku, Oko Cho, Kochi 7838505, Japan Kochi Med Sch Oko Cho Kochi Japan 7838505 Kochi 7838505, Japan
Citazione:
K. Kubota et al., "Evaluation of hepatocellular carcinoma after treatment with transcatheter arterial chemoembolization: comparison of Lipiodol-CT, power Doppler sonography, and dynamic MRI", ABDOM IMAG, 26(2), 2001, pp. 184-190

Abstract

Background: The purpose of this study was to compare the ability of Lipiodol-computed tomography (CT), power Doppler (PD) sonography, and dynamic magnetic resonance imaging (MRI) in evaluating the therapeutic effect of transcatheter arterial chemoembolization (TACE) on hepatocellular carcinoma (HCC). Methods: TACE was performed by injecting an emulsion consisting of Lipiodol and a chemotherapeutic drug, followed by gelatin sponge particles, into 54 patients with 84 HCC lesions. Five to 7 days later, Lipiodol-CT, PD sonography, and dynamic MRI were performed. Findings from the three modalities were correlated with relapse within 1 year after TACE. Results: All lesions with blood flow on PD sonography or intratumoral enhancement on dynamic MRI relapsed regardless of the findings with Lipiodol-CT. None of the negatively enhanced lesions on dynamic MRI relapsed regardless of the Lipiodol-CT findings. However, the readers could not evaluate the contrast uptake in 14 lesions that were already hyperintense on the precontrast images. These cases were considered unsuitable for qualitative assessment and reduced the applicability of MRI to 83% of the examined lesions (70of 84). Although PD sonography perfectly predicted relapse in superficial (0-5 cm from abdominal surface) lesions of the right hepatic lobe, blood flow in deep (>5 cm) or left lobe lesions was undetectable regardless of the occurrence of relapse. As a result, Lipiodol-CT displayed 76.0% sensitivity, 67.6% specificity, and 72.6% accuracy. The sensitivity, specificity, and accuracy of PD sonography were 34.0%, 100%, and 60.7%, respectively, In the70 lesions in which evaluation was possible, dynamic MRI achieved 100% sensitivity, 100% specificity, and 100% accuracy. Conclusion: Of the three modalities, dynamic MRI was the best for evaluating the efficacy of TACE in the treatment of HCC. We also found that superficial lesions of the right lobe are good candidates for PD sonography. However, high signals on precontrast MR images, motion artifacts, and ultrasonicattenuation remain key limitations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:13:43