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Titolo:
Oral delivery of xeno-antigen combined with non-depleting anti-CD4 monoclonal antibody induces significantly prolonged survival of concordant skin xenograft
Autore:
Niimi, M; Shirasugi, N; Hamano, K; Esato, K; Matsumoto, K; Ikeda, Y; Shatari, T; Takami, H; Kodaira, S;
Indirizzi:
Teikyo Univ, Dept Surg 1, Itabashi Ku, Tokyo 1738605, Japan Teikyo Univ Tokyo Japan 1738605 urg 1, Itabashi Ku, Tokyo 1738605, Japan Yamaguchi Univ, Dept Surg 1, Yamaguchi, Japan Yamaguchi Univ Yamaguchi Japan uchi Univ, Dept Surg 1, Yamaguchi, Japan Keio Univ, Dept Surg, Tokyo, Japan Keio Univ Tokyo JapanKeio Univ, Dept Surg, Tokyo, Japan
Titolo Testata:
XENOTRANSPLANTATION
fascicolo: 1, volume: 8, anno: 2001,
pagine: 75 - 79
SICI:
0908-665X(200102)8:1<75:ODOXCW>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; AUTOIMMUNE-DISEASES; TOLERANCE; ANERGY; SUPPRESSION; TOLERIZATION; MECHANISMS; INDUCTION; OVALBUMIN;
Keywords:
anti-CD4 monoclonal antibody; oral tolerance; skin grafts; xenotransplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Niimi, M Teikyo Univ, Dept Surg 1, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan Teikyo Univ 2-11-1 Kaga Tokyo Japan 1738605 Tokyo 1738605, Japan
Citazione:
M. Niimi et al., "Oral delivery of xeno-antigen combined with non-depleting anti-CD4 monoclonal antibody induces significantly prolonged survival of concordant skin xenograft", XENOTRANSPL, 8(1), 2001, pp. 75-79

Abstract

Oral administration can induce unresponsiveness to protein antigens. Therefore, we examined whether oral administration of xeno-antigen could induce the prolonged survival of xenogeneic skin grafts. CBA mice were given 1x10(7) SD rat splenocytes orally, 7 days before transplantation of a SD rat skin in the presence or absence of a nondepleting anti-CD4 monoclonal antibody(mAb) (YTS177, 200 mug/dose, -8 and -7 days relative to transplantation). All skin grafts survived with a median survival time (MST) of 62 days when xeno-antigens were administered orally in combination with anti-CD4 mAb. Mice treated with anti-CD4 mAb alone or oral administration of xeno-antigen alone induced modest prolonged survival of rat skin grafts (MST = 18 and 19 days, respectively) while naive mice rejected rat skin acutely (MST=12 days). Oral administration alone or combined with anti-CD4, mAb reduced the level of xeno-antibody production compared with that in untreated mice after transplantation. Xenogeneic mixed leukocyte response was reduced when splenocytes from mice pre-treated with oral administration of xenogeneic cells were used as the responder compared with that in untreated mice. Oral delivery of xeno-antigen plus nondepleting anti-CD4 mAb can induce prolongation ofconcordant xenogeneic skin grafts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:17:17