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Titolo:
Immunohistochemical localization of platelet-derived endothelial cell growth factor expression and its relation to angiogenesis in prostate
Autore:
Okada, K; Yokoyama, K; Okihara, K; Ukimura, O; Kojima, M; Miki, T; Takamatsu, T;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Pathol & Cell Regulat, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 lat, Kyoto 6028566, Japan Kyoto Prefectural Univ Med, Dept Urol, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 rol, Kyoto 6028566, Japan
Titolo Testata:
UROLOGY
fascicolo: 2, volume: 57, anno: 2001,
pagine: 376 - 381
SICI:
0090-4295(200102)57:2<376:ILOPEC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDINE PHOSPHORYLASE EXPRESSION; HUMAN COLON-CANCER; TUMOR ANGIOGENESIS; RADICAL PROSTATECTOMY; MICROVESSEL DENSITY; PATHOLOGICAL STAGE; BREAST-CANCER; IN-VITRO; CARCINOMA; METASTASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Okada, K Kyoto Prefectural Univ Med, Dept Pathol & Cell Regulat, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 o 6028566, Japan
Citazione:
K. Okada et al., "Immunohistochemical localization of platelet-derived endothelial cell growth factor expression and its relation to angiogenesis in prostate", UROLOGY, 57(2), 2001, pp. 376-381

Abstract

Objectives. Tumor angiogenesis has been reported as a predictor for prognosis in patients with prostate cancer. The aim of this study was to determine the localization of one angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF), in benign and malignant prostatic tissues and the correlation between PD-ECGF expression and microvessel density (MVD) inprostate cancer. Methods. Forty cases of prostate cancer, 3 cases of benign prostatic hyperplasia, and 5 young autopsy cases without prostatic disease were processed with immunohistochemistry, using an anti-PD-ECGF antibody and anti-factor VIII-related antigen antibody. The PD-ECGF expression intensity and MVD wereevaluated in each case. Results. in the 40 cases with prostate cancer, the expression of PD-ECGF was noted in the stromal cells within cancer tissues in 80% of cases. Additionally, noncancerous glands next to cancer lesions were positive for PD-ECGF in 85% of cases. However, cancer cells were negative for PD-ECGF in all cases. In the 8 cases without cancer, both the prostatic glands and their surrounding stroma were positive for PD-ECGF only when they were accompanied by inflammation. There was a significant positive correlation (r = 0.636, P<0.001) between the intensity of PD-ECGF expression and MVD. MVD was significantly different when comparing the intensity of PD-ECGF expression of grade 0 versus grade 1 (P <0.05), grade 1 versus grade 2 (P <0.05), and grade0 versus grade 2 (P <0.01). Conclusions. This study suggested that PD-ECGF expression in the stromal cells within cancer tissues might play an important role in tumor angiogenesis in prostate cancer. UROLOGY 57: 376-381, 2001. (C) 2001, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 23:46:11