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Titolo:
The local lymph node assay and potential application to the identificationof drug allergens
Autore:
Kimber, I;
Indirizzi:
Zeneca Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England Zeneca Cent Toxicol Lab Macclesfield Cheshire England SK10 4TJ e, England
Titolo Testata:
TOXICOLOGY
fascicolo: 1-2, volume: 158, anno: 2001,
pagine: 59 - 64
SICI:
0300-483X(20010202)158:1-2<59:TLLNAA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIZATION RISK ASSESSMENT; CONTACT SENSITIZATION; CHEMICALS; CELL; RESPONSES; MICE; IMMUNOMODULATION; STREPTOZOTOCIN; PROLIFERATION; AUTOIMMUNITY;
Keywords:
local lymph node assay; skin sensitization; drug allergy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kimber, I Zeneca Cent Toxicol Lab, Alderley Pk, Macclesfield SK10 4TJ, Cheshire, England Zeneca Cent Toxicol Lab Alderley Pk Macclesfield Cheshire England SK10 4TJ
Citazione:
I. Kimber, "The local lymph node assay and potential application to the identificationof drug allergens", TOXICOLOGY, 158(1-2), 2001, pp. 59-64

Abstract

The local lymph node assay (LLNA) is a method for the identification of skin sensitization hazard. The method is based upon measurement of proliferative responses induced in draining lymph nudes following topical exposure ofmice to the test chemical. More recently the LLNA has: also been used for the evaluation of relative skin sensitization potency in the context of risk assessment. Idiosyncratic drug reactions resulting from the stimulation of allergic or autoimmunogenic responses are poorly understood but representan important clinical problem. In this article, the potential utility of the LLNA. either in a conventional modified configuration, to provide information of value in assessment the potential for systemic allergenicity is considered. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:59:03