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Titolo:
Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT
Autore:
Shankaran, M; Yamamoto, BK; Gudelsky, GA;
Indirizzi:
Univ Cincinnati, Coll Pharm, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 l Pharm, Cincinnati, OH 45267 USA Case Western Reserve Univ, Dept Psychiat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 40, anno: 2001,
pagine: 55 - 64
SICI:
0887-4476(200104)40:1<55:AAP3(H>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO EVIDENCE; RAT-BRAIN; MDMA ECSTASY; METHYLENEDIOXYMETHAMPHETAMINE MDMA; LIQUID-CHROMATOGRAPHY; P-CHLOROAMPHETAMINE; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; D-FENFLURAMINE; VITAMIN-C;
Keywords:
MDMA; serotonin; antioxidants; hydroxyl radicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Gudelsky, GA Univ Cincinnati, Coll Pharm, 3223 Eden Ave, Cincinnati, OH 45267 USA Univ Cincinnati 3223 Eden Ave Cincinnati OH USA 45267 267 USA
Citazione:
M. Shankaran et al., "Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT", SYNAPSE, 40(1), 2001, pp. 55-64

Abstract

MDMA-induced 5-HT neurotoxicity has been proposed to involve oxidative stress due to increased formation of hydroxyl radicals. Recently, MDMA-induced5-HT neurotoxicity has been shown to be accompanied by a suppression of behavioral and neurochemical responses to a subsequent injection of MDMA. Theintent of the present study was to examine whether suppression of the MDMA-induced formation of hydroxyl radicals by an antioxidant, ascorbic acid, attenuates both the MDMA-induced depletion of 5-HT and the functional consequences associated with this depletion. Treatment of rats with ascorbic acidsuppressed the generation of hydroxyl radicals, as evidenced by the production of 2,3-dihydroxybenzoic acid from salicylic acid, in the striatum during the administration of a neurotoxic regimen of MDMA. Ascorbic acid also attenuated the MDMA-induced depletion of striatal 5-HT content. In rats treated with a neurotoxic regimen of MDMA, the ability of a subsequent injection of MDMA to increase the extracellular concentration of 5-HT in the striatum, elicit the 5-HT behavioral syndrome, and produce hyperthermia was markedly reduced compared to the responses in control rats. The concomitant administration of ascorbic acid with the neurotoxic regimen of MDMA prevented the diminished neurochemical and behavioral responses to a subsequent injection of MDMA. Finally, a neurotoxic regimen of MDMA produced significant reductions in the concentrations of vitamin E and ascorbic acid in the striatum and hippocampus. Thus, the MDMA-induced depletion of brain 5-HT and the functional consequences thereof appear to involve the induction of oxidativestress resulting from an increased generation of free radicals and diminished antioxidant capacity of the brain. (C) 2001 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:17:03