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Titolo:
Detection of response to COMT inhibition in FDOPA PET in advanced Parkinson's disease requires prolonged imaging
Autore:
Ruottinen, HM; Niinivirta, M; Bergman, J; Oikonen, V; Solin, O; Eskola, O; Eronen, E; Sonninen, P; Rinne, UK;
Indirizzi:
Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Neurol, FIN-20520 Turku, Finland Turku PET Ctr, Turku, Finland Turku PET Ctr Turku FinlandTurku PET Ctr, Turku, Finland Univ Turku, Dept Radiol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Radiol, FIN-20520 Turku, Finland
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 40, anno: 2001,
pagine: 19 - 26
SICI:
0887-4476(200104)40:1<19:DORTCI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOL-O-METHYLTRANSFERASE; POSITRON EMISSION TOMOGRAPHY; LEVODOPA THERAPY; ENTACAPONE; METABOLISM; PHARMACOKINETICS; BRAIN; 6-FLUORO-L-DOPA; MONKEYS;
Keywords:
entacapone; COMT inhibition; dopamine storage; fluorodopa positron emission tomography; Parkinson's disease with end-of-dose fluctuations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ruottinen, HM Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 IN-20520 Turku, Finland
Citazione:
H.M. Ruottinen et al., "Detection of response to COMT inhibition in FDOPA PET in advanced Parkinson's disease requires prolonged imaging", SYNAPSE, 40(1), 2001, pp. 19-26

Abstract

The aim was to investigate whether the improved 6-[F-18]fluoro-L-dopa (FDOPA) availability induced by catechol-O-methyltransferase (COMT) inhibition can be more clearly seen during late than during standard (early) imaging in FDOPA uptake in Parkinson's disease (PD) patients with severe dopaminergic hypofunction. Six PD patients and six healthy controls were investigated up to 3.5 h after FDOPA injection with and without a single 400-mg dose of a peripheral COMT inhibitor, entacapone. Prolonged (late) imaging showed a significantly higher increase in FDOPA uptake than standard 1.5 h (early) imaging after entacapone both in controls and in PD patients. The increase in the (putamen-occipital):occipital ratios was 37.4% during early and 70.4%during late imaging in controls. In PD patients, there was no significant change in the ratios during early imaging, but the late imaging showed a significant increase in the putamen-to-occipital ratio of 54.2% after COMT inhibition. Late imaging reveals more clearly the prolonged FDOPA availability induced by COMT inhibition leading to higher cumulated striatal activity compared with early imaging. This might be worth considering in FDOPA studies, especially if investigations are planned to do without blood sampling. Late imaging shows the storing potential of FDA better than is seen during early FDOPA PET imaging after entacapone administration. In patients with severe presynaptic dopaminergic hypofunction, its detection requires prolonged imaging. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:15:19