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Titolo:
Neonatal phencyclidine treatment selectively attenuates mesolimbic dopamine function in adult rats as revealed by methamphetamine-induced behavior and c-fos mRNA expression in the brain
Autore:
Semba, J; Tanaka, N; Wakuta, M; Suhara, T;
Indirizzi:
Univ Air, Div Hlth Sci, Mihama Ku, Chiba 2618586, Japan Univ Air Chiba Japan 2618586 v Hlth Sci, Mihama Ku, Chiba 2618586, Japan Japan Sci & Technol Corp, CREST, Chiba, Japan Japan Sci & Technol Corp Chiba Japan Technol Corp, CREST, Chiba, Japan Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Chiba, Japan Natl Inst Radiol Sci Chiba Japan Adv Technol Med Imaging, Chiba, Japan
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 40, anno: 2001,
pagine: 11 - 18
SICI:
0887-4476(200104)40:1<11:NPTSAM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; MESSENGER-RNA EXPRESSION; NUCLEUS-ACCUMBENS CORE; FREELY MOVING RATS; NMDA RECEPTOR; EXTRACELLULAR DOPAMINE; PROJECTION PATTERNS; NERVOUS-SYSTEM; JAW MOVEMENTS; SHELL;
Keywords:
c-fos; dopamine; neurodevelopment; methamphetamine; phencyclidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Semba, J Univ Air, Div Hlth Sci, Mihama Ku, 2-11 Wakaba, Chiba 2618586, Japan Univ Air 2-11 Wakaba Chiba Japan 2618586 a, Chiba 2618586, Japan
Citazione:
J. Semba et al., "Neonatal phencyclidine treatment selectively attenuates mesolimbic dopamine function in adult rats as revealed by methamphetamine-induced behavior and c-fos mRNA expression in the brain", SYNAPSE, 40(1), 2001, pp. 11-18

Abstract

One of the major hypotheses regarding the pathogenesis of schizophrenia isthe implication of neurodevelopmental abnormality. However, the mechanism of delayed onset of schizophrenic symptoms, in which increased dopaminergicactivity in mesolimbic or mesocortical dopamine systems plays a pathological role, is not known. In this study, we investigated whether the chronic blockade of N-methyl-D-aspartate (NMDA) receptor by phencyclidine (PCP), an NMDA channel blocker, during development could disrupt the dopamine system during later life. Neonatal rats were injected with PCP subcutaneously daily from postnatal day (PD) 1 to PD 14 and their dopaminergic function was evaluated on PD 42 by rating the methamphetamine (MAP)-induced behavior. To illustrate the activated brain regions, the expression of c-fos mRNA in response to a MAP challenge was also studied utilizing in situ hybridization. Chronic neonatal PCP treatment attenuated MAP-induced oral stereotypy (licking and gnawing) and reduced MAP-induced expression of c-fos mRNA in the N. accumbens shell region and VTA but not in the N, accumbens core region, medial striatum, or substantia nigra, These results suggest that neonatal blockade of NMDA receptor, which induces a number of effects in the developing nervous system, may cause long-lasting functional changes of the mesolimbicdopamine system. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:53:06