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Titolo:
Periodic maternal separation of neonatal rats produces region- and gender-specific effects on biogenic amine content in postmortem adult brain
Autore:
Matthews, K; Dalley, JW; Matthews, C; Tsai, TH; Robbins, TW;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England Natl Res Inst Chinese Med, Taipei, Taiwan Natl Res Inst Chinese Med Taipei Taiwan nst Chinese Med, Taipei, Taiwan
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 40, anno: 2001,
pagine: 1 - 10
SICI:
0887-4476(200104)40:1<1:PMSONR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY SOCIAL DEPRIVATION; BEHAVIORAL CONSEQUENCES; ENDURING CHANGES; DOPAMINE; AMPHETAMINE; DEPRESSION; SYSTEMS; RELEASE; STRESS; EXPRESSION;
Keywords:
maternal separation; neurochemistry; isolation rearing; dopamine; noradrenaline; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Matthews, K Univ Dundee, Ninewells Med Sch, Dept Psychiat, Dundee DD1 9SY,Scotland Univ Dundee Dundee Scotland DD1 9SY Dundee DD1 9SY, Scotland
Citazione:
K. Matthews et al., "Periodic maternal separation of neonatal rats produces region- and gender-specific effects on biogenic amine content in postmortem adult brain", SYNAPSE, 40(1), 2001, pp. 1-10

Abstract

Early environment exerts profound effects on mammalian behavioral and neural development. The aim of this study was to describe changes in adult neurochemistry in the rat following repeated neonatal maternal separation (RMS)during the preweaning period, a procedure known to induce enduring behavioral effects. Following RMS, rats show an attenuated locomotor response to novelty, to D-amphetamine, and attenuated behavioral responses for conditioned incentives as adults. These behavioral effects are broadly opposite in direction to those found following postweaning isolation rearing. Isolation rearing-induced behavioral changes are associated with profound changes in central monoamine function. Following RMS, adult rats had increased tissue levels of dopamine in both dorsal and ventral striatum. The turnover of dopamine, as determined by the ratio of DOPAC to dopamine, was decreased in the mPFC of RMS subjects. Serotonin levels were reduced in dorsal hippocampusof RMS rats of both sexes and in the mPFC of male RMS rats. Noradrenaline levels were increased in the dorsal hippocampus in female, but not in male,RMS rats. These data provide evidence that, in addition to the adult behavioral consequences, RMS leads to profound, region-, and gender-specific changes in brain monoamine content. The developmental specificity of these results is discussed with respect to their possible role in altered behavioraldevelopment and psychopathology. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:54:05