Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Antithrombin reduces mesenteric venular leukocyte interactions and small intestine injury in endotoxemic rats
Autore:
Neviere, R; Tournoys, A; Mordon, S; Marechal, X; Song, FL; Jourdain, M; Fourrier, F;
Indirizzi:
Univ Lille 2, Fac Med, Dept Physiol, Pole Rech, F-59045 Lille, France UnivLille 2 Lille France F-59045 siol, Pole Rech, F-59045 Lille, France Ctr Hosp & Univ Lille, Grp Rech, INSERM, EA 2689, Lille, France Ctr Hosp &Univ Lille Lille France Rech, INSERM, EA 2689, Lille, France Ctr Hosp & Univ Lille, Hop R Salengro, Hematol Lab B, Lille, France Ctr Hosp & Univ Lille Lille France lengro, Hematol Lab B, Lille, France Peking Union Med Coll, Chinese Acad Med Sci, Inst Basic Med Sci, Beijing, Peoples R China Peking Union Med Coll Beijing Peoples R China Beijing, Peoples R China
Titolo Testata:
SHOCK
fascicolo: 3, volume: 15, anno: 2001,
pagine: 220 - 225
SICI:
1073-2322(200103)15:3<220:ARMVLI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISSEMINATED INTRAVASCULAR COAGULATION; SEPTIC SHOCK; III PREVENTS; ENDOTHELIAL-CELLS; SEVERE SEPSIS; DOUBLE-BLIND; MECHANISM; ADHESION; ISCHEMIA/REPERFUSION; SUPPLEMENTATION;
Keywords:
antithrombin; intravital microscopy; endotoxin; leukocyte adhesion; coagulation; microvascular; small intestine; permeability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Neviere, R Univ Lille 2, Fac Med, Dept Physiol, Pole Rech, F-59045 Lille, France Univ Lille 2 Lille France F-59045 Rech, F-59045 Lille, France
Citazione:
R. Neviere et al., "Antithrombin reduces mesenteric venular leukocyte interactions and small intestine injury in endotoxemic rats", SHOCK, 15(3), 2001, pp. 220-225

Abstract

We examined the hypothesis that recombinant human antithrombin would reduce mesenteric venule leukocyte adhesion and small intestine injury in endotoxemic rats. Endotoxemic (endotoxin 10 mg/kg, intravenously) rats were treated either with saline or recombinant human antithrombin (250 and 500 U/kg). In some rats, indomethacin (100 mg/kg, intraperitoneally) was injected 60 min prior to endotoxin and recominant human antithrombin (500 U/kg) treatment. Compared to controls, intravital videomicroscopy of the mesentric venule showed an increase of leukocyte rolling (55 +/- 17 versus 70 +/- 19 leukocytes/min; P < 0.05) and firm adhesion (1.1 +/- 0.3 versus 5.8 +/- 0.8 leukocytes/100 <mu>m; P < 0.05) in endotoxemic rats. Recombinant human antithrombin attenuated endotoxin-induced venular endothelium leukocyte adhesive cascade. The beneficial effects of recombinant human antithrombin on leukocyte adhesion were inhibited by indomethacin (100 mg/kg, intraperitoneally) inendotoxemic rats. Endotoxin treatment increased fluorescein isothiocyanate(FITC)-labeled dextran 4,000 (FD4) gut lumen to plasma ratio and wet weight/dry weight ratio. Recombinant human antithrombin (500 U/kg) attenuated endotoxin-induced gut injury. These observations suggest that recombinant human antithrombin reduces endothelium-leukocyte interactions in endotoxemic rats by interacting with local prostacyclin production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:06:25