Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Signal changes of bone marrow in MRI under long-term treatment with granulocyte colony-stimulating factors.
Autore:
Scherer, A; Engelbrecht, V; May, P; Neises, G; Wendel, U; Modder, U;
Indirizzi:
Univ Dusseldorf, Inst Diagnost Radiol, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Dusseldorf, Klin Stoffwechselstorungen & Ernahrung, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Dusseldorf, Klin Allgemeine Padiat, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany
Titolo Testata:
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
fascicolo: 2, volume: 173, anno: 2001,
pagine: 121 - 125
SICI:
1438-9029(200102)173:2<121:SCOBMI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
GER
Soggetto:
HEMATOPOIETIC GROWTH-FACTORS; CHEMOTHERAPY; CHILDREN; THERAPY;
Keywords:
bone marrow; magnetic resonance imaging; glycogen storage disease; granulocyte colony-stimulating factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Scherer, A Univ Dusseldorf, Inst Diagnost Radiol, Moorenstr 5, D-40225 Dusseldorf, Germany Univ Dusseldorf Moorenstr 5 Dusseldorf Germany D-40225 Germany
Citazione:
A. Scherer et al., "Signal changes of bone marrow in MRI under long-term treatment with granulocyte colony-stimulating factors.", ROFO-F RONT, 173(2), 2001, pp. 121-125

Abstract

Purpose: Recurrent infections in patients with glycogen storage disease (GSD) type Ib resulting From an associated neutropenia are frequently treatedwith granulocyte colony-stimulating factors (G-CSF). The aim of this studywas to evaluate the changes occurring in bone marrow by magnetic resonanceimaging (MRI) in these patients. Material and Methods: The distal femoral and tibial bones of six patients with GSD Ib were evaluated by MRI. Four ofthese patients were treated with G-CSF for at least 3.9 to a maximum of 8.2 years (mean 5.8 years). The imaging sequences encompassed spin-echo as well as short-time inversion recovery sequences. 4 of the 6 patients had bonemarrow aspirations. Results: The patients who had undergone therapy with G-CSF showed a marked increase in signal strength in STIR sequences which encompassed the entire medullar cavity. In T-1-weighted images these areas were hypointense. Biopsies obtained from these patients showed a bone marrow hypercellularity. The patients without G-CSF therapy showed the same signalintensity changes but with a more discrete and localized pattern in the metaphyseal cavities, Conclusion: In subjects with GSD Ib, an increased myelopoetic activity of the bone marrow which is intensified under longterm treatment with G-CSF can be demonstrated by MRI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:45:43