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Titolo:
Inhibitory effect of sorbitol on sugar metabolism of Streptococcus mutans in vitro and on acid production in dental plaque in vivo
Autore:
Takahashi-Abbe, S; Abbe, K; Takahashi, N; Tamazawa, Y; Yamada, T;
Indirizzi:
Tohoku Univ, Sch Dent, Dept Oral Biochem, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 em, Sendai, Miyagi 9808575, Japan Tohoku Univ, Sch Dent, Dept Geriatr Dent, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 nt, Sendai, Miyagi 9808575, Japan Tohoku Fukushi Univ, Kansei Fukushi Res Ctr, Div Life Sci, Sendai, Miyagi,Japan Tohoku Fukushi Univ Sendai Miyagi Japan v Life Sci, Sendai, Miyagi,Japan
Titolo Testata:
ORAL MICROBIOLOGY AND IMMUNOLOGY
fascicolo: 2, volume: 16, anno: 2001,
pagine: 94 - 99
SICI:
0902-0055(200104)16:2<94:IEOSOS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRUVATE FORMATE-LYASE; STRICTLY ANAEROBIC CONDITIONS; PH; FERMENTATION; SANGUIS; OXYGEN; DEHYDROGENASE; CONSUMPTION; CITRATE; INVIVO;
Keywords:
dental plaque-pH; acid production; Streptococcus mutans; sorbitol; inhibition; sugar metabolism; sugar-alcohol; pyruvate formate-lyase; NADH/NAD(+) ratio; in-dwelling telemetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi-Abbe, S Tohoku Univ, Sch Dent, Dept Oral Biochem, 4-1 Seiryo Machi, Sendai, Miyagi9808575, Japan Tohoku Univ 4-1 Seiryo Machi Sendai MiyagiJapan 9808575
Citazione:
S. Takahashi-Abbe et al., "Inhibitory effect of sorbitol on sugar metabolism of Streptococcus mutans in vitro and on acid production in dental plaque in vivo", ORAL MICROB, 16(2), 2001, pp. 94-99

Abstract

This study was conducted to find out whether sorbitol inhibits the sugar metabolism of Streptococcus mutans in vitro and the acid production in dental plaque in who. S. mutans NCIB 11723 was anaerobically grown in sorbitol-containing medium. The rate of acid production from sugars was estimated with a pH stat. The rate of acid production from glucose or sucrose was not changed at various concentrations of oxygen. By the addition of sorbitol to sugar, however, the acid production was decreased with increasing levels of oxygen. Intracellular NADH/NAD(+) ratio and (dihydroxyacetone-phosphate+glyceraldehyde-phosphate)/3-phosphoglycerate ratio were high whenever the acidproduction was inhibited by sorbitol. Sorbitol also inhibited the acid production in dental plaque in vivo. These results suggest that the increased NADH/NAD(+) ratio during sorbitol metabolism through the inactivation of pyruvate formate-lyase by oxygen inhibited glyceraldehyde-phosphate dehydrogenase and then the acid production of S. mutans and the one in dental plaque.

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Documento generato il 29/09/20 alle ore 18:25:02