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Titolo:
IFN alpha 2b induces apoptosis and proteasome-mediated degradation of p27(Kip1) in a human lung cancer cell line
Autore:
Moro, A; Perea, SE; Pantoja, C; Santos, A; Arana, MD; Serrano, M;
Indirizzi:
Ctr Ingn Genet & Biotecnol, Havana 10600, Cuba Ctr Ingn Genet & BiotecnolHavana Cuba 10600 otecnol, Havana 10600, Cuba Ctr Nacl Biotecnol, E-28049 Madrid, Spain Ctr Nacl Biotecnol Madrid Spain E-28049 Biotecnol, E-28049 Madrid, Spain
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 2, volume: 8, anno: 2001,
pagine: 425 - 429
SICI:
1021-335X(200103/04)8:2<425:IA2IAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT-KINASE; SENSITIVE HEMATOPOIETIC-CELLS; DAMAGE-INDUCED APOPTOSIS; INTERFERON-ALPHA; INHIBITOR P27(KIP1); GROWTH ARREST; INTERLEUKIN-6 SUPPRESS; POTENTIAL MEDIATOR; PROTEIN-KINASES; CDK6 INHIBITOR;
Keywords:
interferon a 2b; p27(Kipt); apoptosis; cell cycle; H82 cells; Cdk2; c-myc; proteasome inhibitor LLnL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Moro, A Ctr Ingn Genet & Biotecnol, Havana 10600, Cuba Ctr Ingn Genet & Biotecnol Havana Cuba 10600 Havana 10600, Cuba
Citazione:
A. Moro et al., "IFN alpha 2b induces apoptosis and proteasome-mediated degradation of p27(Kip1) in a human lung cancer cell line", ONCOL REP, 8(2), 2001, pp. 425-429

Abstract

IFNs are a family of cytokines involved in antiviral defense, cell growth regulation and immune activation. IFNs either inhibit cell proliferation orcontrol apoptosis depending on factors such as cell type and state of celldifferentiation. It is important to determine how IFN-induced gene products interact with other cellular proteins to produce these responses. We haveinvestigated the effect of IFN alpha 2b on a human small cell lung carcinoma (SCLC) cell line H82. We have found that IFN alpha efficiently induces apoptosis in H82 cells. The induction of apoptosis by IFN alpha 2b is accompanied by decreased levels of c-myc and Cdk2. We have also observed that in H82 cells IFN alpha induces downregulation of p27 and this is in contrast to the upregulation of p27 observed in other cell types where IFNs induce cell cycle arrest. IFN alpha -induced downregulation of p27 is due to proteindestabilization and can be prevented by the proteasome inhibitor LLnL. Thedata suggest that in H82 cells, IFN alpha 2b induces degradation of p27(Kip1) independently of CDK2 kinase activity and through a ubiquitin or ubiquitin-related pathway and that the degradation of p27(Kip1) could be a molecular event of importance for IFN-induced apoptosis in cancer cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:13:53