Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of E-cadherin and beta-catenin in primary and peritoneal metastatic ovarian carcinoma
Autore:
Fujioka, T; Takebayashi, Y; Kihana, T; Kusanagi, Y; Hamada, K; Ochi, H; Uchida, T; Fukumoto, M; Ito, M;
Indirizzi:
Tohoku Univ, Inst Dev Aging & Canc, Dept Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan Ehime Univ, Sch Med, Dept Obstet & Gynecol, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 2, volume: 8, anno: 2001,
pagine: 249 - 255
SICI:
1021-335X(200103/04)8:2<249:EOEABI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; LYMPH-NODE METASTASIS; HEPATOCELLULAR CARCINOMAS; TUMOR DEDIFFERENTIATION; EPITHELIAL-CELLS; GASTRIC-CANCER; ALPHA-CATENIN; MUTATIONS; GENE; APC;
Keywords:
beta-catenin; E-cadherin; ovarian carcinoma; peritoneal metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Fujioka, T Tohoku Univ, Inst Dev Aging & Canc, Dept Pathol, Aoba Ku, 4-1 Seiryomachi,Sendai, Miyagi 9808575, Japan Tohoku Univ 4-1 Seiryomachi SendaiMiyagi Japan 9808575 , Japan
Citazione:
T. Fujioka et al., "Expression of E-cadherin and beta-catenin in primary and peritoneal metastatic ovarian carcinoma", ONCOL REP, 8(2), 2001, pp. 249-255

Abstract

Protein expression levels of E-cadherin and beta -catenin were examined in39 primary and 10 metastatic ovarian carcinoma to elucidate the role of these molecules in the extension of ovarian carcinoma by immunohistochemistry. Twenty-two of 39 (56%) ovarian carcinomas were preserved type and 17 of 39 (44%) were reduced type of E-cadherin. In contrast, 36 of 39 (92%) ovarian carcinomas were preserved type and 3 of 39 (8%) were reduced type of beta-catenin. E-cadherin expression in well-differentiated carcinoma was higher than that in moderately/poorly-differentiated carcinoma (p<0.05). Interestingly, 6 of 10 (60%) peritoneal metastatic lesions resulted in the reducedexpression of E-cadherin compared with primary lesions. In contrast, only 2 of 10 (20%) metastatic lesions showed reduced expression of <beta>-catenin compared with primary lesions. Mutation of exon 3 of beta -catenin gene was rare (3%, 1/39) in carcinoma. These results suggested that the cell adhesion molecule E-cadherin might play an important role in the formation of peritoneal metastasis. In contrast, beta -catenin is not a good indicator ofmetastasis in human ovarian carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 13:27:04