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Titolo:
Monosodium L-glutamate-induced obesity impaired the adrenal medullae activity
Autore:
Martins, ACP; Borges, HE; Garcia, RMG; Carniatto, SR; Mathias, PCF;
Indirizzi:
Univ Estadual Maringa, Dept Cell Biol & Genet, Lab Secret Cell Biol, BR-87020900 Maringa, Parana, Brazil Univ Estadual Maringa Maringa Parana BrazilBR-87020900 BC Parana, Brazil Fed Univ Juiz De Fora, Dept Biol, Juiz De Fora, Brazil Fed Univ Juiz De Fora Juiz De Fora Brazil pt Biol, Juiz De Fora, Brazil
Titolo Testata:
NEUROSCIENCE RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 28, anno: 2001,
pagine: 49 - 58
SICI:
0893-6609(200101/02)28:1<49:MLOITA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; CHROMAFFIN CELLS; HYPOTHALAMIC OBESITY; SYMPATHOADRENAL ACTIVITY; NOREPINEPHRINE TURNOVER; TYROSINE-HYDROXYLASE; GENE-EXPRESSION; ARCUATE NUCLEUS; BRAIN-REGIONS; ZUCKER RATS;
Keywords:
MSG; obesity; mice; catecholamines; secretion; adrenal medulla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Martins, ACP Univ Estadual Maringa, Dept Cell Biol & Genet, Lab Secret Cell Biol, BR-87020900 Maringa, Parana, Brazil Univ Estadual Maringa Maringa Parana Brazil BR-87020900 BCil
Citazione:
A.C.P. Martins et al., "Monosodium L-glutamate-induced obesity impaired the adrenal medullae activity", NEUROSC R C, 28(1), 2001, pp. 49-58

Abstract

Impairment of sympathoadrenomedullar system has been suggested to have a role in obesity. The activity of adrenal medullae (AM) isolated from 90-day-old obese-induced L-monosodium glutamate (MSG) male mice was studied. MSG treatment induced obesity without hyperphagia, while MSG-animals were shorter and lighter than the controls. Catecholamines (CA) gland content decreased in MSG-mice, while secretory response to carbachol was similar in isolated AM of both groups. However, high extracellular potassium did not stimulate CA secretion on AM isolated from obese animals as occurred in controls. Cholinesterase activity of adrenal glands homogenate was impaired in MSG-mice. Results suggest that MSG-hypothalamus lesions could cause impairment of sympathetic transmission in AM, which impose less CA accumulation and altersecretion response in AM. These defects might be involved at the onset of MSG obesity.

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Documento generato il 25/01/20 alle ore 16:11:46