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Titolo:
Effect of vagal autotransplantation on quantitative [H-3]-vesamicol binding image in rats with unilateral lesions of nucleus basalis magnocellularis
Autore:
Ikeda, E; Ichikawa, A; Mori, H; Shiba, K; Kuji, I; Sumiya, H; Tonami, N; Ikeda, K;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Nucl Med, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan Gunma Univ, Sch Med, Dept Nucl Med, Wako, Saitama 3518511, Japan Gunma Univ Wako Saitama Japan 3518511 l Med, Wako, Saitama 3518511, Japan Kanazawa Univ, Sch Med, Radioisotope Ctr, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan Kanazawa Natl Hosp, Dept Neurosurg, Kanazawa, Ishikawa 9208650, Japan Kanazawa Natl Hosp Kanazawa Ishikawa Japan 9208650 shikawa 9208650, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 300, anno: 2001,
pagine: 33 - 36
SICI:
0304-3940(20010302)300:1<33:EOVAOQ>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINERGIC MARKERS; ACETYLCHOLINE; NEURONS; AUTORADIOGRAPHY; PLATES; BRAIN;
Keywords:
Alzheimer's disease; autoradiography; imaging plate system; neurotransplantation; rat; vagal nodosal ganglion; vesamicol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ikeda, E Kanazawa Univ, Sch Med, Dept Nucl Med, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 9208640 n
Citazione:
E. Ikeda et al., "Effect of vagal autotransplantation on quantitative [H-3]-vesamicol binding image in rats with unilateral lesions of nucleus basalis magnocellularis", NEUROSCI L, 300(1), 2001, pp. 33-36

Abstract

It is considered that nodosal ganglion grafting improves learning and memory disorder in nucleus basalis magnocellularis lesioned rats, and that [H-3]-vesamicol is one of the mapping agents for presynaptic cholinergic neurons. Quantitative autoradiography was performed using high sensitive imaging plate system to evaluate the effect of neurotransplantation on [H-3]-vesamicol binding. The affected-side to unaffected-side ratio of [H-3]-vesamicol in the nucleus basalis magnocellularis lesioned group was significantly lower than that in the sham-operated group at 1, 2 and 4 weeks (P < 0.01). In the transplanted group, the ratio was significantly higher than that in theuntreated group at 4 weeks (P < 0.05). [H-3]-vesamicol binding is one of the most sensitive indicators of nucleus basalis magnocellularis lesions andthe effect of the nodosal ganglion grafting. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 11:20:09