Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nitric oxide and substance dependence
Autore:
Uzbay, IT; Oglesby, MW;
Indirizzi:
Gulhane Mil Med Acad, Dept Med Pharmacol, Psychopharmacol Res Unit, TR-06018 Ankara, Turkey Gulhane Mil Med Acad Ankara Turkey TR-06018 nit, TR-06018 Ankara, Turkey Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Denton, TX 76107 USA Univ N Texas Denton TX USA 76107 armacol & Neurosci, Denton, TX 76107 USA
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 1, volume: 25, anno: 2001,
pagine: 43 - 52
SICI:
0149-7634(200101)25:1<43:NOASD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICOTINE ABSTINENCE SYNDROME; ETHANOL WITHDRAWAL SYNDROME; EXHIBITS ANTINOCICEPTIVE ACTIVITY; CONDITIONED PLACE PREFERENCE; NMDA RECEPTOR ANTAGONIST; RAT LOCUS-COERULEUS; SYNTHASE INHIBITION; ALCOHOL-WITHDRAWAL; OPIOID WITHDRAWAL; L-ARGININE;
Keywords:
amphetamine; cocaine; ethanol; nicotine; nitric oxide; nitric oxide synthase inhibitors; opioid(s); physical dependence; substance abuse; substance withdrawal;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Uzbay, IT Gulhane Mil Med Acad, Dept Med Pharmacol, Psychopharmacol Res Unit, TR-06018 Ankara, Turkey Gulhane Mil Med Acad Ankara Turkey TR-06018 018 Ankara, Turkey
Citazione:
I.T. Uzbay e M.W. Oglesby, "Nitric oxide and substance dependence", NEUROSCI B, 25(1), 2001, pp. 43-52

Abstract

The free-radical gas nitric oxide (NO) plays an important role in a diverse range of physiological processes. it is synthesized from the precursor L-arginine by the enzyme NO synthase (NOS), which transforms L-arginine into NO and citrulline. This synthetic pathway exists in the central nervous system (CNS), and NO appears to be a messenger molecule in the CNS, fulfillingmost of the criteria of a neurotransmitter. Recent studies indicate that NO may play an important role in dependence on drugs of abuse. The purpose of this review is to address the role of NO in dependence on substances suchas opioids, ethanol, psychostimulants and nicotine. Inhibitors of NOS modulate withdrawal from opioids and ethanol, diminishing many signs of withdrawal. In addition, NOS inhibitors suppress signs of withdrawal from nicotine. These data suggest that NO may be involved in the expression of withdrawal signs, and they leave open the possibility that NO may mediate the development of many of these signs. Although preliminary, data to date suggest that glutamate neurotransmission may be related to these beneficial effects of NOS inhibitors on signs of withdrawal. Emerging data further suggest thatNO may have a general role in the dependence potential of various classes of drugs of abuse. Thus, modulation of NO systems may be a potential therapeutic target for treatment of substance abuse. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:00:44