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Titolo:
Orexin A immunoreactivity and prepro-orexin mRNA in the brain of Zucker and WKY rats
Autore:
Taheri, S; Gardiner, J; Hafizi, S; Murphy, K; Dakin, C; Seal, L; Small, C; Ghatei, M; Bloom, S;
Indirizzi:
Hammersmith Hosp, Imperial Coll Sch Med, Div Invest Sci, Endocrine Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN ne Unit, London W12 0NN, England
Titolo Testata:
NEUROREPORT
fascicolo: 3, volume: 12, anno: 2001,
pagine: 459 - 464
SICI:
0959-4965(20010305)12:3<459:OAIAPM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANIN-CONCENTRATING HORMONE; RECEPTOR MESSENGER-RNA; CENTRAL-NERVOUS-SYSTEM; CANINE NARCOLEPSY; SLEEP; HYPOTHALAMUS; MICE; NEUROPEPTIDE; EXPRESSION; NEURONS;
Keywords:
hypocretins; locomotor activity; obesity; orexin A immunoreactivity; orexins; prepro-orexin mRNA; sleep; WKY rats; Zucker rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bloom, S Hammersmith Hosp, Imperial Coll Sch Med, Div Invest Sci, Endocrine Unit, Du Cane Rd, London W12 0NN, England Hammersmith Hosp Du Cane Rd London England W12 0NN 0NN, England
Citazione:
S. Taheri et al., "Orexin A immunoreactivity and prepro-orexin mRNA in the brain of Zucker and WKY rats", NEUROREPORT, 12(3), 2001, pp. 459-464

Abstract

The primary role of the orexins was originally believed to be appetite regulation. but is now believed to be the regulation of sleep, arousal and locomotor activity. Orexin A immunoreactivity (orexin A-IR) and prepro-orexin mRNA were measured in the CNS of obese and lean Zucker rats. There were no differences in orexin A-IR or prepro-orexin mRNA levels between obese and lean Zucker rats. The orexins are therefore unlikely to be important in thismodel of obesity. Levels of orexin A-IR and prepro-orexin mRNA were measured in the CNS of Wistar-Kyoto (WKY) rats, which are hypoactive and have abnormal sleep architecture. Compared to Wistar rats, WKY rats had significantly lower orexin A-IR (with differences of up to 100% in some brain regions)and prepro-orexin mRNA levels. These observations suggest that the sleep and activity phenotype of the WKY strain may be related to orexin deficiencyand that this strain may be a useful model of partial orexin deficiency. NeuroReport 12:459-464 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 18/01/20 alle ore 10:40:04