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Titolo:
The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease
Autore:
Murphy, T; Yip, A; Brayne, C; Easton, D; Evans, JG; Xuereb, J; Cairns, N; Esiri, MM; Rubinsztein, DC;
Indirizzi:
Wellcome Trust Ctr Mol Mechanisms Dis, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 2XY, England Wellcome Trust Ctr Mol Mechanisms Dis Cambridge England CB2 2XY England Addenbrookes Hosp, Dept Pathol, Cambridge CB2 2XY, England Addenbrookes Hosp Cambridge England CB2 2XY , Cambridge CB2 2XY, England Dept Publ Hlth & Primary Care, Cambridge CB2 2SR, England Dept Publ Hlth &Primary Care Cambridge England CB2 2SR CB2 2SR, England Univ Cambridge, Dept Publ Hlth & Primary Care, CRC, Genet Epidemiol Unit,Strangeways Res Lab, Cambridge CB1 8RN, England Univ Cambridge Cambridge England CB1 8RN Lab, Cambridge CB1 8RN, England Radcliffe Infirm, Dept Clin Geratol, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE Geratol, Oxford OX2 6HE, England Radcliffe Infirm, Dept Neuropathol, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE opathol, Oxford OX2 6HE, England Inst Psychiat, MRC, Brain Bank, Dept Neuropathol, London SE5 8AF, England Inst Psychiat London England SE5 8AF europathol, London SE5 8AF, England
Titolo Testata:
NEUROREPORT
fascicolo: 3, volume: 12, anno: 2001,
pagine: 631 - 634
SICI:
0959-4965(20010305)12:3<631:TBGGSA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; BETA-SECRETASE;
Keywords:
Alzheimer's disease; amyloid; BACE; dementia; MRC CFAS study; beta-secretase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Rubinsztein, DC Wellcome Trust Ctr Mol Mechanisms Dis, Cambridge Inst Med Res, Dept Med Genet, Wellcome MRC Bldg, Cambridge CB2 2XY, England WellcomeTrust Ctr Mol Mechanisms Dis Wellcome MRC Bldg Cambridge England CB2 2XY
Citazione:
T. Murphy et al., "The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease", NEUROREPORT, 12(3), 2001, pp. 631-634

Abstract

Alzheimer's disease (AD) pathology is characterized by beta -amyloid plaques and neurofibrillary tangles. Studies of autosomal dominant early-onset AD mutations suggest that beta -amyloid overproduction is sufficient to cause AD. Recently, the BACE gene. which encodes beta -secretase, the rate limiting enzyme in beta -amyloid formation. has been identified. Since this gene is a strong candidate gene for late-onset AD because of its function, we have characterized its genomic organization and identified two polymorphisms. Neither of these polymorphisms were associated with AD risk in generic association studies comparing autopsy-confirmed late-onset AD cases and age-matched non-demented controls. Thus, we find no evidence that this locus influences risk for late-onset AD. NeuroReport 12:631-634 (C) 2001 LippincottWilliams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:40:25