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Titolo:
Vesicle-associated proteins and transmitter release from sympathetic ganglionic boutons
Autore:
Blair, DH; Robson, S; King, G; Bennett, MR;
Indirizzi:
Univ Sydney, Neurobiol Lab, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ol Lab, Sydney, NSW 2006, Australia Univ Sydney, Inst Biomed Res, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ed Res, Sydney, NSW 2006, Australia Univ Sydney, Dept Physiol, Sydney, NSW 2006, Australia Univ Sydney SydneyNSW Australia 2006 hysiol, Sydney, NSW 2006, Australia Univ Sydney, Dept Biochem, Sydney, NSW 2006, Australia Univ Sydney SydneyNSW Australia 2006 iochem, Sydney, NSW 2006, Australia
Titolo Testata:
NEUROREPORT
fascicolo: 3, volume: 12, anno: 2001,
pagine: 607 - 610
SICI:
0959-4965(20010305)12:3<607:VPATRF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUID GIANT SYNAPSE; NEUROTRANSMITTER RELEASE; QUANTAL SECRETION; MEMBRANE-FUSION; ACTIVE ZONE; ALPHA-SNAP; SYNTAXIN; PROBABILITY; EXOCYTOSIS; DROSOPHILA;
Keywords:
boutons; ganglia; SNARE proteins; vesicles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Bennett, MR Univ Sydney, Neurobiol Lab, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ey, NSW 2006, Australia
Citazione:
D.H. Blair et al., "Vesicle-associated proteins and transmitter release from sympathetic ganglionic boutons", NEUROREPORT, 12(3), 2001, pp. 607-610

Abstract

A method is reported for introducing peptides derived from SNARE proteins that control exocytosis of vesicles at boutons formed by sympathetic ganglion cells in tissue culture. These peptides were coupled to the DNA binding domain of the Drosophila transcription factor antennapedia, called penetratin, This facilitated the passage of peptides across the bouton membrane. FMI-43 was used to monitor the exocytosis of transmitter from depolarized boutons after their exposure to the penetratin-peptide sequences IETRHNEIIKLETSIRELHD of syntaxin and KGFLSSLFGGSSK of alpha -SNAP. both of which blockedsecretion, whereas the peptide sequences SELDDRA-DALQAGASQFETSAAKLKRK of synaptobrevin did not. This report introduces a readily applicable method for determining the effect of different peptide sequences of vesicle-associated proteins on secretion at vertebrate boutons and presents an account of the effects of a selection of such peptides on exocytosis. NeuroReport 12:607-610 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:19:44