Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GT1b ganglioside induces death of dopaminergic neurons in rat mesencephalic cultures
Autore:
Chung, ES; Joe, EH; Ryu, JK; Kim, J; Lee, YB; Cho, KG; Oh, YJ; Maeng, SH; Baik, HH; Kim, SU; Jin, BK;
Indirizzi:
Ajou Univ, Sch Med, Brain Dis Res Ctr, Suwon 442749, South Korea Ajou Univ Suwon South Korea 442749 is Res Ctr, Suwon 442749, South Korea Ajou Univ, Sch Med, Dept Pharmacol, Suwon 442749, South Korea Ajou Univ Suwon South Korea 442749 Pharmacol, Suwon 442749, South Korea Ajou Univ, Sch Med, Dept Neurosurg, Suwon 442749, South Korea Ajou Univ Suwon South Korea 442749 Neurosurg, Suwon 442749, South Korea Yonsei Univ, Coll Sci, Dept Biol, Seoul 120749, South Korea Yonsei Univ Seoul South Korea 120749 ept Biol, Seoul 120749, South Korea Seoul Natl Univ, Coll Med, Dept Pharmacol, Seoul 110799, South Korea SeoulNatl Univ Seoul South Korea 110799 acol, Seoul 110799, South Korea Kyung Hee Univ, Coll Med, Dept Biochem, Seoul 130701, South Korea Kyung Hee Univ Seoul South Korea 130701 ochem, Seoul 130701, South Korea
Titolo Testata:
NEUROREPORT
fascicolo: 3, volume: 12, anno: 2001,
pagine: 611 - 614
SICI:
0959-4965(20010305)12:3<611:GGIDOD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED NEUROTOXICITY; TYROSINE-HYDROXYLASE; MICROGLIA; BRAIN; THYMOCYTES; MECHANISM; APOPTOSIS;
Keywords:
dopaminergic neurons; microglia; nitric oxide (NO); tissue culture; trisialoganglioside (GT1b); Tyrosine hydroxylase (TH);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, BK Ajou Univ, Sch Med, Brain Dis Res Ctr, Suwon 442749, South Korea Ajou Univ Suwon South Korea 442749 tr, Suwon 442749, South Korea
Citazione:
E.S. Chung et al., "GT1b ganglioside induces death of dopaminergic neurons in rat mesencephalic cultures", NEUROREPORT, 12(3), 2001, pp. 611-614

Abstract

We examined neurotoxicity of GT1b against dopaminergic neurons in vitro. Cultures of mesencephalic cells deprived of serum underwent the loss of 19% of tyrosine hydroxylase immunopositive (TH-ip) neurons. In cultures deprived of serum. treatment with 10-30 mug/ml GT1b attenuated the number of TH-ipneurons by 26-69%, respectively. compared to non-treated cultures. Intriguingly, cultures deprived of serum were more vulnerable to GT1b-induced neurotoxicity. Application of 60 mug/ml GT1b to cultures grown in serum containing media resulted in the loss of 26% of TH-ip neurons, similar to that (28%) observed in serum-deprived cultures treated with 10 mug/ml GT1b. Moreover, in our cultures, absence of nitric oxide (NO) production after GT1b treatment was obvious. The present results strongly suggest direct neurotoxic actions of GT1b against dopaminergic neurons regardless of NO. NeuroReport 12:611-614 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 10:01:20