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Titolo:
Postsynaptic K+ current induced by nociceptin in medullary dorsal horn neurons
Autore:
Jennings, EA;
Indirizzi:
Univ Sydney, Dept Pharmacol, Sydney, NSW 2000, Australia Univ Sydney Sydney NSW Australia 2000 rmacol, Sydney, NSW 2000, Australia
Titolo Testata:
NEUROREPORT
fascicolo: 3, volume: 12, anno: 2001,
pagine: 645 - 648
SICI:
0959-4965(20010305)12:3<645:PKCIBN>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANTIA-GELATINOSA NEURONS; RAT SPINAL-CORD; ORL(1) RECEPTOR; IN-VITRO; SYNAPTIC TRANSMISSION; ORL1 ANTAGONIST; ORPHANIN FQ; J-113397; POTENT; LIGAND;
Keywords:
analgesia; dorsal horn; nociceptin; nocistatin; ORL1; pain; trigeminal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Jennings, EA Univ Sydney, Dept Pharmacol, Sydney, NSW 2000, Australia UnivSydney Sydney NSW Australia 2000 y, NSW 2000, Australia
Citazione:
E.A. Jennings, "Postsynaptic K+ current induced by nociceptin in medullary dorsal horn neurons", NEUROREPORT, 12(3), 2001, pp. 645-648

Abstract

The actions of the endogenous ORL1 receptor (opioid receptor-like(1)) ligand nociceptin on the membrane properties of rat trigeminal nucleus caudalisneurons were examined by use of whole cell and perforated patch clamp recording in brain slices. Nociceptin produced an outward current in all neurons tested (EC50 112 nM). The outward current produced by nociceptin was completely reversed with the addition of the non-peptide ORL1 antagonist j-113397. Outward currents reversed polarity at -99 +/- 2 mV, close to the potential for K+ of -102 mV, suggesting that they were mediated by an increased K conductance. These results suggest that the analgesic action of nociceptin might be mediated by direct postsynaptic inhibition within the dorsal horn. NeuroReport 12:645-648 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 23:22:40