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Titolo:
Estrogenic activity of tamoxifen and raloxifene on rat brain AMPA receptors
Autore:
Cyr, M; Morissette, M; Landry, M; Di Paolo, T;
Indirizzi:
Univ Laval, Med Ctr, Oncol & Mol Endocrinol Res Ctr, St Foy, PQ G1V 4G2, Canada Univ Laval St Foy PQ Canada G1V 4G2 l Res Ctr, St Foy, PQ G1V 4G2, Canada Univ Laval, Fac Pharm, St Foy, PQ G1V 4G2, Canada Univ Laval St Foy PQ Canada G1V 4G2 Fac Pharm, St Foy, PQ G1V 4G2, Canada
Titolo Testata:
NEUROREPORT
fascicolo: 3, volume: 12, anno: 2001,
pagine: 535 - 539
SICI:
0959-4965(20010305)12:3<535:EAOTAR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; NERVOUS-SYSTEM; ION CHANNELS; EXPRESSION; HYPOTHALAMUS; MODULATION; STEROIDS; ROLES; GENE;
Keywords:
AMPA receptors; autoradiography; estrogen; frontal cortex; ovariectomy; menopause; raloxifene; schizophrenia; tamoxifen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Di Paolo, T Univ Laval, Med Ctr, Oncol & Mol Endocrinol Res Ctr, 2705 Laurier Blvd, StFoy, PQ G1V 4G2, Canada Univ Laval 2705 Laurier Blvd St Foy PQ Canada G1V 4G2 , Canada
Citazione:
M. Cyr et al., "Estrogenic activity of tamoxifen and raloxifene on rat brain AMPA receptors", NEUROREPORT, 12(3), 2001, pp. 535-539

Abstract

We have previously shown in rats that estradiol has brain regionally specific effects on AMPA receptors. The present study investigated hormonal specificity of AMPA receptors by comparing the effect of estradiol with tamoxifen or raloxifene, which have varying effects on estrogen response in breast, bone and uterus. Ovariectomy in rats decreased uterus weight which was restored by estradiol treatment, whereas tamoxifen and raloxifene had only a weak effect. Ovariectomy left unchanged AMPA receptor specific binding in rat brain whereas estradiol, tamoxifen and raloxifene decreased it in cortical and striatal regions of ovariectomized rats. Hence. tamoxifen and raloxifene showed agonist estrogenic activity on AMPA receptors in specific brainregions, which can be dissociated from their antagonist estrogenic activity in the periphery. NeuroReport 12:535-539 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:33:31