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Titolo:
Plasma concentrations of interleukin-1 beta, interleukin-6, soluble interleukin-2 receptor and tumor necrosis factor alpha of depressed patients in Japan
Autore:
Kagaya, A; Kugaya, A; Takebayashi, M; Fukue-Saeki, M; Saeki, T; Yamawaki, S; Uchitomi, Y;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Psychiat & Neurosci, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan Natl Canc Ctr, Res Inst E, Psychooncol Div, Kashiwa, Chiba, Japan Natl Canc Ctr Kashiwa Chiba Japan Psychooncol Div, Kashiwa, Chiba, Japan
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 2, volume: 43, anno: 2001,
pagine: 59 - 62
SICI:
0302-282X(2001)43:2<59:PCOIBI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSION; CYTOKINE PRODUCTION; DISORDER; SYSTEM;
Keywords:
Interleukin-1 beta; interleukin-6; soluble interleukin-2 receptor; tumor necrosis factor alpha; depressed patients;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kugaya, A Hiroshima Univ, Sch Med, Dept Psychiat & Neurosci, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan Hiroshima Univ 1-2-3 Kasumi HiroshimaJapan 7348551 8551, Japan
Citazione:
A. Kagaya et al., "Plasma concentrations of interleukin-1 beta, interleukin-6, soluble interleukin-2 receptor and tumor necrosis factor alpha of depressed patients in Japan", NEUROPSYCHB, 43(2), 2001, pp. 59-62

Abstract

There are a number of investigations which indicate the important relationship between depression and cytokines. In this study, we investigated plasma interleukin (IL)-1 beta, IL-6, soluble IL-2 receptor (sIL-2R) and tumor necrosis factor (TNF)-alpha of depressed patients whose clinical evaluation was performed by the Hamilton Rating Scale for Depression (HAM-D) and the Profile of Mood States (POMS). They were compared with those of the control subjects, and before and after treatment with antidepressants. Before the treatment, plasma IL-1 beta, IL-6, sIL-2R and TNF-alpha of the patients werenot significantly different from those of the control subjects, sIL-2R waspositively correlated with the POMS-tension-anxiety subscale and tended tohave a positive correlation with HAM-D. After pharmacotherapy, TNF-alpha levels of the depressed patients increased, without any relationship betweenthe change in the HAM-D or the POMS and change in TNF-alpha. These resultssuggest that the plasma sIL-2R concentration is associated with mood state, and that the plasma TNF-alpha concentration is increased after pharmacotherapy in Japanese depressed patients. Copyright (C) 2001 S. Karger AG. Basel.

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Documento generato il 22/01/20 alle ore 13:10:48