Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein
Autore:
Cha, JHJ; Farrell, LA; Ahmed, SF; Frey, A; Hsiao-Ashe, KK; Young, AB; Penney, JB; Locascio, JJ; Hyman, BT; Irizarry, MC;
Indirizzi:
Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 t Neurol, Boston, MA 02114 USA Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Neurol, Minneapolis, MN 55455 USA MIT, Dept Brain & Cognit Sci, Cambridge, MA USA MIT Cambridge MA USAMIT, Dept Brain & Cognit Sci, Cambridge, MA USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 90 - 102
SICI:
0969-9961(200102)8:1<90:GRDITH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; ALZHEIMERS-DISEASE; BINDING-SITES; QUANTITATIVE AUTORADIOGRAPHY; NEUROTRANSMITTER RECEPTORS; HUNTINGTON-DISEASE; NEURONAL LOSS; RAT; EXPRESSION; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Irizarry, MC Massachusetts Gen Hosp E, Alzheimer DIs Rwes Unit, CNY 6028,149 13th St, Charlestown, MA 02129 USA Massachusetts Gen Hosp E CNY 6028,14913th St Charlestown MA USA 02129
Citazione:
J.H.J. Cha et al., "Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein", NEUROBIOL D, 8(1), 2001, pp. 90-102

Abstract

Alzheimer's disease transgenic mice overexpressing human amyloid precursorprotein (hAPP) with the Swedish double mutation (hAPP(Sw)) develop age-related amyloid deposition and behavioral and electrophysiologic changes by anunknown mechanism. Analysis of glutamatergic receptor subtypes in 4- and 15-month-old heterozygous hAPP(Sw) transgenic mice revealed a selective increase in AMPA receptor binding in the hippocampus of 15-month-old transgenicmice, which have established cortical and hippocampal amyloid deposits. There were no significant alterations of GluR1, GluR2, and GluR4 protein expression by semiquantitative confocal analysis or GluR1 mRNA by in situ hybridization. There was no significant alteration in NMDA, in group I and II metabotropic glutamate and in muscarinic receptor binding, or in striatal dopamine and adenosine receptor binding in 15-month-old mice. These data suggest that mutant APP overexpression or age-related amyloid deposition producea subtle specific alteration in hippocampal glutamate receptors with aging. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:28:34