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Titolo:
Perinatal human hypoxia-ischemia vulnerability correlates with brain calcification
Autore:
Rodriguez, MJ; Ursu, G; Bernal, F; Cusi, V; Mahy, N;
Indirizzi:
Univ Barcelona, Fac Med, Inst Invest Biomed August Pi & Sunyer, Unit Bioquim, Barcelona 7, Spain Univ Barcelona Barcelona Spain 7 unyer, Unit Bioquim, Barcelona 7, Spain Hosp St Joan Deu, Serv Anat Patol, Barcelona, Spain Hosp St Joan Deu Barcelona Spain Deu, Serv Anat Patol, Barcelona, Spain
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 59 - 68
SICI:
0969-9961(200102)8:1<59:PHHVCW>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIA CALCIFICATION; EXCITATORY AMINO-ACIDS; CYTOSOLIC FREE CALCIUM; X-RAY-MICROANALYSIS; CEREBRAL-ISCHEMIA; GLUTAMATE RECEPTORS; GLUCOSE-METABOLISM; NEONATAL RAT; COMPUTED-TOMOGRAPHY; ELECTRON-MICROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Rodriguez, MJ Univ Barcelona, Fac Med, Inst Invest Biomed August Pi & Sunyer, Unit Bioquim, Barcelona 7, Spain Univ Barcelona Barcelona Spain 7 oquim, Barcelona 7, Spain
Citazione:
M.J. Rodriguez et al., "Perinatal human hypoxia-ischemia vulnerability correlates with brain calcification", NEUROBIOL D, 8(1), 2001, pp. 59-68

Abstract

Deregulation of intracellular calcium homeostasis is widely considered as one of the underlying pathophysiological mechanisms of hypoxic-ischemic brain injury. Whether this alteration can result in cerebral calcification wasinvestigated in basal ganglia, cerebral cortex, and hippocampus of human premature and term neonates together with glial reaction, in all samples nonarteriosclerotic calcifications were observed, their number and size were area-specific and increased in term neonates. Basal ganglia always presentedthe highest degree of calcification and hippocampus the lowest, located mainly in the CA1 subfield. In all cases, neuronal damage was associated withastroglial reaction and calcium precipitates, with microglial reaction only in basal ganglia and cerebral cortex, and argues for the participation ofexcitatory amino acid receptors in hypoxia-ischemia damage. These data correlate with hypoxia-ischemia vulnerability in the perinatal period. The clinical relevance of these precipitates and the neuroprotective interest of non-NMDA receptor manipulation are discussed in the light of our results. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:25:34