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Titolo:
Regional and subunit-specific downregulation of acid-sensing ion channels in the pilocarpine model of epilepsy
Autore:
Biagini, G; Babinski, K; Avoli, M; Marcinkiewicz, M; Seguela, P;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Inst, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada Univ Montreal, Clin Res Inst Montreal, Biochem Neuroendocrinol Lab, Montreal, PQ H2W 1R7, Canada Univ Montreal Montreal PQ Canada H2W 1R7 ab, Montreal, PQ H2W 1R7, Canada Univ Modena & Reggio Emila, Dept Biomed Sci, Physiol Sect, I-41100 Modena,Italy Univ Modena & Reggio Emila Modena Italy I-41100 ct, I-41100 Modena,Italy Antalium Inc, Montreal, PQ H3A 1X6, Canada Antalium Inc Montreal PQ Canada H3A 1X6 Inc, Montreal, PQ H3A 1X6, Canada
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 45 - 58
SICI:
0969-9961(200102)8:1<45:RASDOA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED STATUS EPILEPTICUS; GATED NA+ CHANNEL; MUTATIONS CAUSING NEURODEGENERATION; MAMMALIAN DEGENERIN MDEG; RECEPTOR SUBUNIT; CATION CHANNEL; CAENORHABDITIS-ELEGANS; MOLECULAR-CLONING; SEIZURE ACTIVITY; SENSORY NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Biagini, G McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 2B4, Canada
Citazione:
G. Biagini et al., "Regional and subunit-specific downregulation of acid-sensing ion channels in the pilocarpine model of epilepsy", NEUROBIOL D, 8(1), 2001, pp. 45-58

Abstract

Acid-sensing ion channels (ASICs) constitute a recently discovered family of excitatory cation channels, structurally related to the superfamily of degenerin/epithelial sodium channels. ASIC1b and ASIC3 are highly expressed in primary sensory neurons and are thought to play a role in pain transmission related to acidosis. ASIC1a, ASIC2a, and ASIC2b are also distributed inthe central nervous system where their function remains unclear. We investigated here the regulation of their expression during status epilepticus (SE), a condition in which neuronal overexcitation leads to acidosis. In animals treated with pilocarpine (380 mg/kg) to induce SE, we observed a markeddecrease of ASlC2b mRNA levels in all hippocampal areas and of ASIC1a mRNAlevels in the CA1-2 fields. These changes were also observed after protective treatment from neuronal cell death with diazepam (10 mg/kg) and pentobarbital (30 mg/kg). These findings suggest a key role of channels containingASIC1a and ASIC2b subunits in both normal and pathological activity of hippocampus. (C) 2001 Academic Press.

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Documento generato il 09/04/20 alle ore 13:02:13