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Titolo:
Coexpression of human cdk5 and its activator p35 with human protein tau inneurons in brain of triple transgenic mice
Autore:
Van den Haute, C; Spittaels, K; Van Dorpe, J; Lasrado, R; Vandezande, K; Laenen, I; Geerts, H; Van Leuven, F;
Indirizzi:
Katholieke Univ Leuven, Flemish Inst Biotechnol VIB, Ctr Human Genet, ExptGenet Grp, B-3000 Louvain, Belgium Katholieke Univ Leuven Louvain BelgiumB-3000 p, B-3000 Louvain, Belgium Janssen Res Fdn, B-2340 Beerse, Belgium Janssen Res Fdn Beerse Belgium B-2340 en Res Fdn, B-2340 Beerse, Belgium
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 32 - 44
SICI:
0969-9961(200102)8:1<32:COHCAI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT KINASE-5; PAIRED HELICAL FILAMENTS; AMYLOID PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; REGULATORY SUBUNIT; CDC2-LIKE KINASE; NERVOUS-SYSTEM; NEUROFIBRILLARY TANGLES; NEUROFILAMENT PROTEINS; MONOCLONAL-ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Van den Haute, C Katholieke Univ Leuven, Flemish Inst Biotechnol VIB, Ctr Human Genet, ExptGenet Grp, Gasthuisberg O&N 06, B-3000 Louvain, Belgium Katholieke Univ Leuven Gasthuisberg O&N 06 Louvain Belgium B-3000
Citazione:
C. Van den Haute et al., "Coexpression of human cdk5 and its activator p35 with human protein tau inneurons in brain of triple transgenic mice", NEUROBIOL D, 8(1), 2001, pp. 32-44

Abstract

The potential contribution of cyclin-dependent protein kinase 5 (cdk5) to hyperphosphorylate protein tau, as claimed in Alzheimer's disease, was investigated in vivo. We generated single, double, and triple transgenic mice that coexpress human cdk5 and its activator p35 as well as human protein tauin cerebral neurons. Whereas expression and increased cdk5-kinase activitywas obtained, as measured in vitro and demonstrated in vivo neither murinenor human protein tau was appreciably phosphorylated in the brain of double and triple transgenic mice. These mice behaved and reproduced normally. Silver impregnation and immunohistochemistry of brain sections demonstrated that neurofilament proteins became redistributed in apical dendrites of cortical neurons. This suggested a cytoskeletal effect, but no other relevant brain pathology became apparent. These observations indicate that cdk5/p35 is not a major protein tau kinase and that cdk5/p35 did not cause neurodegeneration in mouse brain, as opposed to cdk5/p25. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:56:36