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Titolo:
Cathepsin B and L and stefin A and B levels as serum tumor markers in squamous cell carcinoma of the head and neck
Autore:
Strojan, P; Budinha, M; Smid, L; Svetic, B; Vrhovec, I; Skrk, J;
Indirizzi:
Inst Oncol, Dept Radiotherapy, SI-1000 Ljubljana, Slovenia Inst Oncol Ljubljana Slovenia SI-1000 erapy, SI-1000 Ljubljana, Slovenia Univ Dept Otorhinolaryngol & Cervicofacial Surg, SI-1000 Ljubljana, Slovenia Univ Dept Otorhinolaryngol & Cervicofacial Surg Ljubljana Slovenia SI-1000 Inst Oncol, Dept Biochem, SI-1000 Ljubljana, Slovenia Inst Oncol Ljubljana Slovenia SI-1000 ochem, SI-1000 Ljubljana, Slovenia Inst Oncol, Dept Tumor Biol, SI-1000 Ljubljana, Slovenia Inst Oncol Ljubljana Slovenia SI-1000 Biol, SI-1000 Ljubljana, Slovenia
Titolo Testata:
NEOPLASMA
fascicolo: 1, volume: 48, anno: 2001,
pagine: 66 - 71
SICI:
0028-2685(2001)48:1<66:CBALAS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTEINE PROTEINASE-INHIBITORS; ENDOGENOUS INHIBITORS; COLORECTAL-CANCER; CYSTATIN-C; PROGNOSIS;
Keywords:
cathepsins; head and neck carcinoma; prognosis; stefins; tumor marker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Strojan, P Inst Oncol, Dept Radiotherapy, SI-1000 Ljubljana, Slovenia InstOncol Ljubljana Slovenia SI-1000 000 Ljubljana, Slovenia
Citazione:
P. Strojan et al., "Cathepsin B and L and stefin A and B levels as serum tumor markers in squamous cell carcinoma of the head and neck", NEOPLASMA, 48(1), 2001, pp. 66-71

Abstract

Cysteine proteinases cathepsin (Cath) B and L and their endogenous inhibitors stefin (Stef) A and B concentrations were measured using a quantitativeimmunosorbent assay (ELISA; KRKA d.d., Novo mesto, Slovenia) in serum samples from 35 patients with primary and 7 patients with recurrent squamous cell carcinoma of the head and neck (SCCHN), obtained at diagnosis (Serum no.1) and after therapy (Serum no. 2), and compared to sera from 30 (Stef B, 90) healthy volunteers. A significantly higher StefA (P = 0.005) and lower StefB (P < 0.001) concentrations were measured in patients' Serum no.1 than in controls, and the levels of Caths B and L and Stef A were found to be significantly elevated in Serum no.1 as compared to Serum no. 2 (P = 0.045, P= 0.041 and P = 0.024, respectively). The time of Serum no.2 collection did not influence the concentration of either Caths or Stefs in these samples, and no correlation was observed with the established prognostic factors for any of the parameters studied. Patients with subsequently diagnosed recurrent disease had a significantly lower Cath L concentration than those without evidence of relapse during follow up (P = 0.05). The risk of disease recurrence and SCCHN-related death correlated significantly with low Cath L serum levels (P = 0.012, P = 0.006). The serum levels of Cath B, Stef A andStef B did not influence significantly the probability of survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:41:42