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Titolo:
The potential use of mutation spectra in cancer related genes in genetic toxicology: a statement of a GUM working group
Autore:
Hartwig, A; Kasper, P; Madle, S; Speit, G; Staedtler, F; Sengstag, C;
Indirizzi:
Univ Karlsruhe, Inst Lebensmittelchem & Toxikol, D-76128 Karlsruhe, Germany Univ Karlsruhe Karlsruhe Germany D-76128 kol, D-76128 Karlsruhe, Germany BfArM, Berlin, Germany BfArM Berlin GermanyBfArM, Berlin, Germany BgVV, Berlin, Germany BgVV Berlin GermanyBgVV, Berlin, Germany Univ Ulm, Abt Humangenet, Ulm, Germany Univ Ulm Ulm GermanyUniv Ulm, Abt Humangenet, Ulm, Germany Novartis Pharma AG, Preclin Safety, Basel, Switzerland Novartis Pharma AGBasel Switzerland Preclin Safety, Basel, Switzerland ETH Zurich, Inst Toxikol, Zurich, Switzerland ETH Zurich Zurich Switzerland Zurich, Inst Toxikol, Zurich, Switzerland
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 2, volume: 473, anno: 2001,
pagine: 263 - 267
SICI:
1386-1964(20010220)473:2<263:TPUOMS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-HA-RAS; B6C3F1 MICE; MOLECULAR PATHOGENESIS; METHYLENE-CHLORIDE; P53 MUTATIONS; LUNG-TUMORS; SKIN TUMORS; PROTOONCOGENE; COMPENSABILITY; ETIOLOGY;
Keywords:
mutation spectra; carcinogenicity; oncogenes and tumor suppressor genes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Hartwig, A Univ Karlsruhe, Inst Lebensmittelchem & Toxikol, Postfach 6980,D-76128 Karlsruhe, Germany Univ Karlsruhe Postfach 6980 Karlsruhe GermanyD-76128 Germany
Citazione:
A. Hartwig et al., "The potential use of mutation spectra in cancer related genes in genetic toxicology: a statement of a GUM working group", MUT RES-F M, 473(2), 2001, pp. 263-267

Abstract

In recent years, there has been widespread interest in the relationship between carcinogenic exposure and mutation spectra in cancer-related genes. To evaluate potential benefits and/or limitations in the use of mutation spectra in genetic toxicology, a GUM working group has been established to discuss this subject. Based on methodological possibilities and limitations, the impact of mutation spectra in the interpretation of animal experiments and in the identification of etiological agents in human cancer has been considered. With respect to experimental animals, the analyses of mutation spectra within long-term rodent carcinogenicity studies may provide some additional information on the mode of action of the respective carcinogen, however, the interpretation of results should be done carefully and only in context with other toxicological data available. Regarding human exposure, the analysis of mutation spectra in p53 or ras genes supplies information on the genotoxic properties of the respective agent. Nevertheless, on the individual level, the presence or absence of defined mutations in cancer-related genes in human tumors does not permit a definite conclusion about the causative agent. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:23:35