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Titolo:
Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro
Autore:
Kim, HFS; Weeber, EJ; Sweatt, JD; Stoll, AL; Marangell, LB;
Indirizzi:
Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 t & Behav Sci, Houston, TX 77030 USA Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Dept Neurosci, Houston, TX 77030 USA McLean Hosp, Psychopharmacol Res Lab, Belmont, MA 02178 USA McLean Hosp Belmont MA USA 02178 pharmacol Res Lab, Belmont, MA 02178 USA Harvard Univ, Sch Med, Dept Psychiat, Boston, MA USA Harvard Univ Boston MA USA Univ, Sch Med, Dept Psychiat, Boston, MA USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 2, volume: 6, anno: 2001,
pagine: 246 - 248
SICI:
1359-4184(200103)6:2<246:IEOOFA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOOD-STABILIZING AGENTS; SIGNAL-TRANSDUCTION PATHWAYS; IN-VITRO; BIPOLAR DISORDER; LITHIUM; OMEGA-3-FATTY-ACIDS; ALPHA; HIPPOCAMPUS; CNS;
Keywords:
omega-3 fatty acids; protein kinase C; eicosapentaenoic acid; docosahexaenoic acid; arachidonic acid; valproic acid; lithium; bipolar disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Marangell, LB Dept Psychiat, 1 Baylor Plaza,BCM 350, Houston, TX 77030 USADept Psychiat 1 Baylor Plaza,BCM 350 Houston TX USA 77030 SA
Citazione:
H.F.S. Kim et al., "Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro", MOL PSYCHI, 6(2), 2001, pp. 246-248

Abstract

Preliminary clinical data indicate that omega-3 fatty acids may be effective mood stabilizers for patients with bipolar disorder. Both lithium and valproic acid are known to inhibit protein kinase C (PKC) activity after subchronic administration in cell culture and in vivo. The current study was undertaken to determine the effects of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on protein kinase C phosphotransferase activity in vitro. Various concentrations of DHA, EPA, and arachidonic acid (AA) were incubated with the catalytic domain of protein kinase Cbeta from rat brain. Protein kinase C activity was measured by quantifyingincorporation of (32)p-pO(4) into a synthetic peptide substrate. Both DHA and EPA, as well as the combination of DHA and EPA, inhibited PKC activity at concentrations as low as 10 mu mol l(-1). In contrast, arachidonic acid had no effect on PKC activity. Thus, PKC represents a potential site of action of omega-3 fatty acids in their effects on the treatment of bipolar disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:02:46