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Titolo:
Functional polymorphism within the promotor of the serotonin transporter gene is associated with severe hyperkinetic disorders
Autore:
Seeger, G; Schloss, P; Schmidt, MH;
Indirizzi:
Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat, D-68072 Mannheim,Germany Cent Inst Mental Hlth Mannheim Germany D-68072 D-68072 Mannheim,Germany Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68072 Mannheim, Germany Cent Inst Mental Hlth Mannheim Germany D-68072 D-68072 Mannheim, Germany Univ Heidelberg, Fac Clin Med Mannheim, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 im, D-6900 Heidelberg, Germany
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 2, volume: 6, anno: 2001,
pagine: 235 - 238
SICI:
1359-4184(200103)6:2<235:FPWTPO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; OBSESSIVE-COMPULSIVE DISORDER; REGULATORY REGION; CHILDREN; FLUOXETINE; AGGRESSION; EXPRESSION; SUICIDE; SAMPLE; ADHD;
Keywords:
hyperkinetic disorder; conduct disorder; serotonin transporter gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Seeger, G Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat, POB 12 21 20, D-68072 Mannheim, Germany Cent Inst Mental Hlth POB 12 21 20 Mannheim Germany D-68072 any
Citazione:
G. Seeger et al., "Functional polymorphism within the promotor of the serotonin transporter gene is associated with severe hyperkinetic disorders", MOL PSYCHI, 6(2), 2001, pp. 235-238

Abstract

In children and adolescents, hyperkinetic disorder (HD) with conduct disorder (CD) and without CD and attention-deficit/hyperactivity disorder (ADHD)is known to be comorbid with psychiatric disorders (anxiety, depression, aggression), some of which are related to disturbed serotonergic neurotransmission. The efficiency of serotonergic signalling relates to the concentration of the neurotransmitter in the synaptic cleft and is controlled by the serotonin transporter (5-HTT), which selectively removes serotonin out of the synaptic cleft. ' The activity of serotonin transport itself has been shown to be also controlled by a 5-HTT-linked polymorphism in its promotor region with a L/L genotype yielding higher levels of 5-HTT function than do L/S or S/S genotypes.(2) Considering an association between 5-HTT polymorphism, serotonergic neurotransmission and HD +/- CD, we genotyped for 5-HTT polymorphism and compared patients with controls. In contrast to the distribution of L/L: L/S: S/S in controls (0.245: 0.509: 0.245), we found an enhanced expression of the L/L genotype in HD patients with CD (0.393: 0.304: 0.304; chi (2) = 7.603; P = 0.0211) and a significant overexpression of L/L in HD without CD (0.542: 0.333: 0.125; chi (2) = 9.127; P = 0.0092), To our knowledge, this is the first finding providing evidence for an association between the 5-HTT polymorphism and hyperkinetic disorder, implying that serotonergic neurotransmission might be affected in this desease. As a consequence, for a successful treatment of these patients one should now also consider drugs which specifically modulate serotonergic signalling such as selective serotonin reuptake inhibitors.

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Documento generato il 26/01/20 alle ore 00:47:36