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Titolo:
Extrapyramidal symptoms and antidepressant drugs: neuropharmacological aspects of a frequent interaction in the elderly
Autore:
Govoni, S; Racchi, M; Masoero, E; Zamboni, M; Ferini-Strambi, L;
Indirizzi:
Univ Pavia, Dept Expt & Appl Pharmacol, Pavia, Italy Univ Pavia Pavia Italy Pavia, Dept Expt & Appl Pharmacol, Pavia, Italy San Raffaele Sci Inst, Dept Neurol, I-20132 Milan, Italy San Raffaele Sci Inst Milan Italy I-20132 t Neurol, I-20132 Milan, Italy
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 2, volume: 6, anno: 2001,
pagine: 134 - 142
SICI:
1359-4184(200103)6:2<134:ESAADN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-2/D-3 RECEPTOR ANTAGONIST; PARKINSONS-DISEASE; PHOSPHORYLATION SYSTEM; TARDIVE-DYSKINESIA; LIMBIC SELECTIVITY; DEPRESSED-PATIENTS; DOPAMINE RELEASE; H-3 PAROXETINE; AMISULPRIDE; BINDING;
Keywords:
elderly; depression; movement disorders; Parkinson's disease; antidepressant drugs; extrapyramidal symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Govoni, S Dept Pharmacol, Viale Taramelli 14, I-27100 Pavia, Italy Dept Pharmacol Viale Taramelli 14 Pavia Italy I-27100 ia, Italy
Citazione:
S. Govoni et al., "Extrapyramidal symptoms and antidepressant drugs: neuropharmacological aspects of a frequent interaction in the elderly", MOL PSYCHI, 6(2), 2001, pp. 134-142

Abstract

Depression is the most prevalent functional psychiatric disorder in late rife. The problem of motor disorders associated with antidepressant use is relevant in the elderly. Elderly people are physically more frail and more likely to be suffering from physical illness, and any drug given may exacerbate pre-existing diseases, or interact with other drug treatments being administered for physical conditions. Antidepressants have been reported to induce extrapyramidal symptoms, including parkinsonism. These observations prompted us to review the neurobiological mechanism that may be involved in this complex interplay including neurotransmitters and neuronal circuits involved in movement and emotion control and their changes related to aging and disease. The study of the correlations between motor and mood disorders and their putative biochemical bases, as presented in this review, provide arationale either to understand or to foresee motor side effects for psychotropic drugs, in particular antidepressants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:34:46