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Titolo:
Dermatan sulphate is released by proteinases of common pathogenic bacteriaand inactivates antibacterial alpha-defensin
Autore:
Schmidtchen, A; Frick, IM; Bjorck, L;
Indirizzi:
Univ Lund, Biomed Ctr, Dept Cell & Mol Biol, Sect Mol Pathogenesis, SE-22184 Lund, Sweden Univ Lund Lund Sweden SE-22184 t Mol Pathogenesis, SE-22184 Lund, Sweden Univ Lund Hosp, Dept Dermatol & Venereol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 atol & Venereol, S-22185 Lund, Sweden
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 3, volume: 39, anno: 2001,
pagine: 708 - 713
SICI:
0950-382X(200102)39:3<708:DSIRBP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR CYSTEINE PROTEASE; PSEUDOMONAS-AERUGINOSA IFO-3455; NUCLEOTIDE-SEQUENCE; SKIN FIBROBLASTS; STRUCTURAL GENE; HIGH-AFFINITY; SULFATE; PROTEOGLYCANS; ACTIVATION; GELATINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidtchen, A Univ Lund, Biomed Ctr, Dept Cell & Mol Biol, Sect Mol Pathogenesis, B14,Tornavagen 10, SE-22184 Lund, Sweden Univ Lund B14,Tornavagen 10 Lund Sweden SE-22184 d, Sweden
Citazione:
A. Schmidtchen et al., "Dermatan sulphate is released by proteinases of common pathogenic bacteriaand inactivates antibacterial alpha-defensin", MOL MICROB, 39(3), 2001, pp. 708-713

Abstract

Defensins represent an evolutionarily conserved group of small peptides with potent antibacterial activities. We report here that extracellular proteinases secreted by the human pathogens Pseudomonas aeruginosa, Enterococcusfaecalis and Streptococcus pyogenes release dermatan sulphate by degradingdermatan sulphate-containing proteoglycans, such as decorin. Dermatan sulphate was found to bind to neutrophil-derived alpha -defensin, and this binding completely neutralized its bactericidal activity. During infection, proteoglycan degradation and release of dermatan sulphate may therefore represent a previously unknown virulence mechanism, which could serve as a targetfor novel antibacterial strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:25:33