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Titolo:
Dexamethasone alters TNF-alpha expression in retinopathy
Autore:
Yossuck, P; Tadesse, YYM; Higgins, RD;
Indirizzi:
Georgetown Univ, Childrens Med Ctr, Dept Pediat, Div Neonatol, Washington,DC 20007 USA Georgetown Univ Washington DC USA 20007 Neonatol, Washington,DC 20007 USA
Titolo Testata:
MOLECULAR GENETICS AND METABOLISM
fascicolo: 2, volume: 72, anno: 2001,
pagine: 164 - 167
SICI:
1096-7192(200102)72:2<164:DATEIR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; PROLIFERATIVE DIABETIC-RETINOPATHY; OXYGEN-INDUCED RETINOPATHY; ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS; MOUSE; RATS; SUPPRESSION; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Higgins, RD Georgetown Univ, Childrens Med Ctr, Dept Pediat, Div Neonatol,3800 Reservoir Rd NW,Room M3400, Washington, DC 20007 USA Georgetown Univ 3800 Reservoir Rd NW,Room M3400 Washington DC USA 20007
Citazione:
P. Yossuck et al., "Dexamethasone alters TNF-alpha expression in retinopathy", MOL GEN MET, 72(2), 2001, pp. 164-167

Abstract

TNF-alpha has been found in the retina. Hyperoxia and hypoxia regulate TNF-alpha expression. TNF-alpha is an important factor in inflammation and angiogenesis. Dexamethasone inhibits TNF-alpha production. Changes in TNF-alpha expression in the retina may play an important role in the development ofoxygen-induced retinopathy. Oxygen-induced retinopathy was produced in C57BL6 mice by exposure to 75% oxygen at Postnatal Day 7 (P7) for 5 days and the mice recovered in room air until Day 17 (P17). Dexamethasone was administered at 0.5 mg/kg/day once daily subcutaneously during the 5 days of oxygen exposure. TNF-alpha expression was evaluated at Day 7 prior to oxygen exposure, at Day 12 (P12) immediately upon removal from oxygen, and at Day 17,the time of maximal vasoproliferation by RT-PCR. TNF-alpha is developmentally regulated in the retinae of C57BL6 mice. From P7 to P12, there is a 3-fold increase in TNF-alpha expression and from P7 to P17 there is a 2.7-foldincrease. There was 2.7-fold suppression in expression immediately following oxygen exposure at P12. The expression was dramatically increased at P17, the time of maximal vasoproliferation. Dexamethasone inhibited the expression of TNF-alpha at P17 by 6.4-fold. At this dose, it also suppressed the baseline TNF-alpha expression in the mouse model. In summary, TNF-alpha is altered in the development of oxygen-induced retinopathy in the mouse. It increased markedly during the vasoproliferative phase and was suppressed by dexamethasone. Modulation of TNF-alpha expression may provide a potential site of action for future therapeutic targets. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:13:50