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Titolo:
The clinical, morphologic, and molecular changes in the ileum associated with early postnatal dexamethasone administration: From the baby's bowel to the researcher's bench
Autore:
Gordon, PV; Marshall, DD; Stiles, AD; Price, WA;
Indirizzi:
Univ Virginia, Dept Pediat, Div Neonatol, Charlottesville, VA USA Univ Virginia Charlottesville VA USA v Neonatol, Charlottesville, VA USA Univ N Carolina, Dept Pediat, Div Neonatal Perinatal Med, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA al Perinatal Med, Chapel Hill, NC USA
Titolo Testata:
MOLECULAR GENETICS AND METABOLISM
fascicolo: 2, volume: 72, anno: 2001,
pagine: 91 - 103
SICI:
1096-7192(200102)72:2<91:TCMAMC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; LOW-BIRTH-WEIGHT; NEONATAL INTESTINAL PERFORATION; SUCRASE-ISOMALTASE GENE; BRUSH-BORDER ENZYMES; EPITHELIAL-CELL LINE; CHRONIC LUNG-DISEASE; SMOOTH-MUSCLE CELLS; NECROTIZING ENTEROCOLITIS; BINDING-PROTEINS;
Keywords:
dexamethasone; indomethacin; focal small bowel perforation; insulin-like growth factor; ileum;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Gordon, PV UVA Hlth Syst, Dept Pediat, Div Neonatol, POB 800386, Charlottesville, VA 22908 USA UVA Hlth Syst POB 800386 Charlottesville VA USA 22908 22908 USA
Citazione:
P.V. Gordon et al., "The clinical, morphologic, and molecular changes in the ileum associated with early postnatal dexamethasone administration: From the baby's bowel to the researcher's bench", MOL GEN MET, 72(2), 2001, pp. 91-103

Abstract

Focal small bowel perforation (FSBP) is a life-threatening event that predominantly affects extremely low birth weight (ELBW) infants. Histopathologyfrom surgical specimens of ileum with FSBP shows a healthy mucosa overlying a thinned muscularis with segmental degeneration. Clinical data strongly support an association between early postnatal administration of dexamethasone (EPD) and FSBP. Additional risk factors, including gestational age, administration of prophylactic indomethacin, and severity of illness, may be synergistic with EPD for the pathogenesis of perforations. Animal models of dexamethasone administration show morphologic changes in the ileum, similarto those seen in ELBW infants, including increased mucosal maturation and thinning of the muscularis. These tissue-specific differences may be mediated by a perturbation in growth factor expression or accumulation. In support of this hypothesis, dexamethasone has been associated with increased IGF-I immunolocalization in the mucosa and decreased immunolocalization in the muscularis. The known growth-promoting functions of IGF-I are consistent with the observed dexamethasone-associated changes within both the mucosa andthe muscularis. Ongoing studies in this animal model are exploring the potential mechanisms by which dexamethasone might affect IGF-I availability. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:01:08