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Titolo:
Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: Involvement of nonsterol isoprenoid biosynthesis inhibition
Autore:
Garcia-Roman, N; Alvarez, AM; Toro, MJ; Montes, A; Lorenzo, MJ;
Indirizzi:
Univ Extremadura, Fac Vet, Dept Bioquim & Biol Mol, E-10071 Caceres, SpainUniv Extremadura Caceres Spain E-10071 Biol Mol, E-10071 Caceres, Spain Univ Alcala de Henares, Dept Bioquim & Biol Mol, E-28871 Alcala De Henares, Madrid, Spain Univ Alcala de Henares Alcala De Henares Madrid Spain E-28871 drid, Spain Univ Alcala de Henares, Dept Fisiol, E-28871 Alcala De Henares, Madrid, Spain Univ Alcala de Henares Alcala De Henares Madrid Spain E-28871 drid, Spain Univ Complutense Madrid, Ctr Citometria Flujo & Microscopia Confocal, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 ocal, E-28040 Madrid, Spain
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 2, volume: 17, anno: 2001,
pagine: 329 - 341
SICI:
1044-7431(200102)17:2<329:LIAOSI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
COENZYME-A REDUCTASE; LEMLI-OPITZ SYNDROME; SMOOTH-MUSCLE CELLS; CHOLESTEROL-BIOSYNTHESIS; COMPETITIVE INHIBITOR; MEVALONATE PATHWAY; IN-VITRO; BCL-X; GROWTH; RHO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Lorenzo, MJ Univ Extremadura, Fac Vet, Dept Bioquim & Biol Mol, Ave Univ S-N, E-10071 Caceres, Spain Univ Extremadura Ave Univ S-N Caceres Spain E-10071 es, Spain
Citazione:
N. Garcia-Roman et al., "Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: Involvement of nonsterol isoprenoid biosynthesis inhibition", MOL CELL NE, 17(2), 2001, pp. 329-341

Abstract

We have examined the effects of lovastatin and pravastatin (competitive HMG-CoA reductase inhibitors) on the growth and survival of rat brain neuroblasts. Lovastatin, but not pravastatin, suppressed cell growth by inducing apoptosis of neuroblasts in a dose- and time-dependent manner. Apoptosis wasaccompanied by a decrease in both Bcl-2 and Bcl-xL protein levels, suggesting that changes in the expression of these genes may contribute to apoptosis following lovastatin treatment. Lovastatin treatment was also associatedwith decreased prenylation of both Ras and Rho A proteins whereas Rac 1 geranylgeranylation was not affected. Lovastatin effects were fully preventedby mevalonate. The present data suggest that lovastatin induces apoptosis of rat brain neuroblasts by its capacity to decrease the prenylation of specific proteins involved in signal transduction pathways that control growthand survival of neuronal cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/08/20 alle ore 02:37:46