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Titolo:
Malignant glioma biology: Role for TGF-beta in growth, motility, angiogenesis, and immune escape
Autore:
Platten, M; Wick, W; Weller, M;
Indirizzi:
Univ Tubingen, Sch Med, Dept Neurol, Mol Neurooncol Lab, D-72076 Tubingen,Germany Univ Tubingen Tubingen Germany D-72076 col Lab, D-72076 Tubingen,Germany
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 4, volume: 52, anno: 2001,
pagine: 401 - 410
SICI:
1059-910X(20010215)52:4<401:MGBRFT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY INTRACRANIAL TUMORS; HUMAN GLIOBLASTOMA CELLS; LIMITED-VOLUME IRRADIATION; NATURAL-KILLER-CELLS; SMOOTH-MUSCLE CELLS; TRANSFORMING GROWTH-FACTOR-BETA-1; IN-VITRO; T-CELLS; COLLAGEN-SYNTHESIS; SUPPRESSOR FACTOR;
Keywords:
transforming growth factor-beta; metalloproteinases; tranilast; decorin; immune system;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Platten, M Univ Tubingen, Sch Med, Dept Neurol, Mol Neurooncol Lab, Hoppe Seyler Str 3, D-72076 Tubingen, Germany Univ Tubingen Hoppe Seyler Str 3 Tubingen Germany D-72076 many
Citazione:
M. Platten et al., "Malignant glioma biology: Role for TGF-beta in growth, motility, angiogenesis, and immune escape", MICROSC RES, 52(4), 2001, pp. 401-410

Abstract

Characteristics of human malignant glioma are excessive proliferation, infiltrative growth, angiogenesis and suppression of anti-tumor immune surveillance. Transforming growth factor-beta (TGF-beta), a versatile cytokine, isintimately involved in the regulation of these processes. Here, we discussthe interactions of TGF-beta with growth factors, such as basic fibroblastgrowth factor (bFGF), epidermal growth factor (EGF) and platelet derived growth factor (PDGF), metalloproteinases (MMP-2, MMP-9) and their inhibitor,plasmin activator inhibitor-1 (PAI-1), and immune cells, like natural killer cells, T-cells and microglia. The differential effects of TGF-beta in glioma biology are outlined with emphasis on the induction of a survival advantage for glioma cells by enforced cell growth, migration, invasion, angiogenesis and immune paralysis. By virtue of its growth regulatory and immunomodulatory properties, TGF-beta promises to become a novel target for the experimental therapy of human malignant glioma. Microsc. Res. Tech. 52:401-410, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:09:11