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Titolo:
Positive and negative aspects of the human immunodeficiency virus protease: Development of inhibitors versus its role in AIDS pathogenesis
Autore:
Ikuta, K; Suzuki, S; Horikoshi, H; Mukai, T; Luftig, RB;
Indirizzi:
Osaka Univ, Res Inst Microbial Dis BIKEN, Dept Virol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 t Virol, Suita, Osaka 5650871, Japan Hokkaido Univ, Inst Immunol Sci, Sect Serol, Kita Ku, Sapporo, Hokkaido 0600815, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600815 oro, Hokkaido 0600815, Japan Louisiana State Univ, Med Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
fascicolo: 4, volume: 64, anno: 2000,
pagine: 725 -
SICI:
1092-2172(200012)64:4<725:PANAOT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM SURVIVORS; CD4(+) T-CELLS; BLOOD MONONUCLEAR-CELLS; SYNCYTIUM-INDUCING PHENOTYPE; HIV-INFECTED PERSONS; LYMPHOCYTE SURFACE MOLECULES; HUMAN SALIVARY SECRETIONS; AMINO-ACID SUBSTITUTIONS; ACCESSORY GENE-MUTATIONS; VITRO SERIAL PASSAGE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
384
Recensione:
Indirizzi per estratti:
Indirizzo: Ikuta, K Osaka Univ, Res Inst Microbial Dis BIKEN, Dept Virol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
K. Ikuta et al., "Positive and negative aspects of the human immunodeficiency virus protease: Development of inhibitors versus its role in AIDS pathogenesis", MICRO M B R, 64(4), 2000, pp. 725

Abstract

In this review we summarize multiple aspects of the human immunodeficiencyvirus (HIV) protease from bath structural and functional viewpoints. Afteran introductory overview, we provide an up-to-date status report on protease inhibitors (PI). This proceeds from a discussion of PI structural design, to how PI are optimally utilized in highly active antiretroviral triple therapy (one PI along with two reverse transcriptase inhibitors), the emergence of PI resistance, and the natural role of secretory leukocyte PI. Then we switch to another focus: the interaction of HIV protease with other genes in acute and persistent infection, which in turn may have an effect on AIDS pathogenesis. We conclude with a discussion on future directions in HIV treatment, involving multiple-target anti-HIV therapy, vaccine development,and novel reactivation-inhibitory reagents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:43:01