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Titolo:
Mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains isolated in Brazil and France
Autore:
de Miranda, SS; Kritski, A; Filliol, I; Mabilat, C; Panteix, G; Drouet, E;
Indirizzi:
Univ Fed Minas Gerais, Fac Med, Dept Clin Med Pneumol, BR-30130100 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil BR-30130100 BC, MG, Brazil UFRJ, Hosp Univ Clementino Fraga Filho, Rio De Janeiro, Brazil UFRJ Rio De Janeiro Brazil ementino Fraga Filho, Rio De Janeiro, Brazil Lab bioMerieux, Lyon, France Lab bioMerieux Lyon FranceLab bioMerieux, Lyon, France Lab Marcel Merieux, Lyon, France Lab Marcel Merieux Lyon FranceLab Marcel Merieux, Lyon, France Univ Grenoble 1, Fac Pharm, Grenoble, France Univ Grenoble 1 Grenoble France Grenoble 1, Fac Pharm, Grenoble, France
Titolo Testata:
MEMORIAS DO INSTITUTO OSWALDO CRUZ
fascicolo: 2, volume: 96, anno: 2001,
pagine: 247 - 250
SICI:
0074-0276(200102)96:2<247:MITRGO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-RESISTANCE; RAPID DETECTION; HIV; MECHANISMS;
Keywords:
Mycobacterium tuberculosis; rpoB gene; rifampicin-resistant; Brazil; France;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: de Miranda, SS Univ Fed Minas Gerais, Fac Med, Dept Clin Med Pneumol, Rua Alfredo Balena 190, BR-30130100 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Rua Alfredo Balena 190 Belo Horizonte MG Brazil BR-30130100 BC
Citazione:
S.S. de Miranda et al., "Mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains isolated in Brazil and France", MEM I OSW C, 96(2), 2001, pp. 247-250

Abstract

We evaluated the mutations in a 193bp of the rpoB gene by automated sequencing of rifampicin (RMP)-resistant and susceptible Mycobacterium tuberculosis strains isolated from Brazil (25 strains) and France (37 strains). In RMP-resistant strains, mutations were identified in 100% (16/16) from France and 89% (16/18) from Brazil. No mutation was detected in the 28 RMP-susceptible strains. Among RMP-resistant or RMP-susceptible strains deletion was observed. A double point mutation which had not been reported before was detected in one strain from France. Among French resistant strains mutations were found in codons 531 (31.2%), 526 513 and 533 (18.7% each). In Brazilianstrains the most common mutations were in codons 531 (72.2%), 526 (11.1%) and 513 (5.5%). The heterogeneity found in French strains may be related tothe fact that most of those strains were from African or Asian patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:13:20