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Titolo:
B cell subsets in postmenopausal women and the effect of hormone replacement therapy
Autore:
Kamada, M; Irahara, M; Maegawa, M; Yasui, T; Yamano, S; Yamada, M; Tezuka, M; Kasai, Y; Deguchi, K; Ohmoto, Y; Aono, T;
Indirizzi:
Univ Tokushima, Sch Med, Dept Obstet & Gynecol, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 Gynecol, Tokushima 7708503, Japan Otsuka Pharmaceut Co Ltd, Cellular Technol Inst, Tokushima 77101, Japan Otsuka Pharmaceut Co Ltd Tokushima Japan 77101 t, Tokushima 77101, Japan
Titolo Testata:
MATURITAS
fascicolo: 3, volume: 37, anno: 2001,
pagine: 173 - 179
SICI:
0378-5122(20010131)37:3<173:BCSIPW>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-CONTROL; IMMUNE FUNCTION; ESTROGEN; AGE; AUTOANTIBODIES; ANTIBODIES; STEROIDS; MICE;
Keywords:
CD5(+) B cell; B-2 cell; B-1 cell; autoimmune disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kamada, M Univ Tokushima, Sch Med, Dept Obstet & Gynecol, 3-18-15 KuramotoCho, Tokushima 7708503, Japan Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japan 7708503 pan
Citazione:
M. Kamada et al., "B cell subsets in postmenopausal women and the effect of hormone replacement therapy", MATURITAS, 37(3), 2001, pp. 173-179

Abstract

Objectives: In elderly subjects the capacity for antibody production is depressed. This immunosenescence state of humoral immunity is associated withthe occurrence of autoimmune disorders involving CD5(+) B (B-1) cells. Since estrogen is capable of stimulating the production of autoantibodies. this sex steroid hormone may be a contributing cause of the higher incidence of autoimmune diseases in women. In the present study. B cell subsets in women during the postmenopausal period was determined. The effect of hormone replacement therapy (HRT) on B cell subsets was examined to establish whether the administration of gonadal hormones influence humoral immunity in postmenopausal women. Methods: Forty six untreated pre- and postmenopausal women and 39 women on HRT were studied. The proportion of B-1 (CD5(+)) and conventional CD5(-) B (B-2) lymphocytes was determined by two-color flow cytometry. Serum autoantibodies to a nuclear antigen and to interleukin (IL)-1 alpha were measured by immunofluorescence and by radioimmunoassay, respectively. Thirteen women were examined prospectively before and during HRT. Results: In late postmenopausal women (greater than or equal to 30 years postmenopausal period). the proportion of B-2 cells was significantly reduced (p <0.01) compared to those of premenopausal and perimenopausal women. HRT induced a significant (p < 0.01) increase in the percentage of B-2 cells, while that of B-1 cells remained unchanged. HRT did not affect autoantibody production. Conclusion: HRT may retard the progress of immunosenescence by increasing the production of B-2 cells. Moreover. HRT appears not to increase the risk of autoimmune diseases developing in postmenopausal women. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:51:13