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Titolo:
Integrins and signal transduction: illustration with the alpha(IIb)beta(3)integrin in platelets
Autore:
Missy, K; Giuriato, S; Bodin, S; Plantavid, M; Payrastre, B;
Indirizzi:
Hop Purpan, INSERM, U326, F-31059 Toulouse, France Hop Purpan Toulouse France F-31059 NSERM, U326, F-31059 Toulouse, France
Titolo Testata:
M S-MEDECINE SCIENCES
fascicolo: 2, volume: 17, anno: 2001,
pagine: 155 - 161
SICI:
0767-0974(200102)17:2<155:IASTIW>2.0.ZU;2-W
Fonte:
ISI
Lingua:
FRE
Soggetto:
GLYCOPROTEIN-IIB-IIIA; THROMBIN-STIMULATED PLATELETS; FOCAL ADHESION KINASE; HUMAN BLOOD-PLATELETS; PHOSPHOINOSITIDE 3-KINASE; TYROSINE PHOSPHORYLATION; CYTOPLASMIC DOMAIN; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOLIPASE C-GAMMA-2; ACTIVATED PLATELETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Payrastre, B Hop Purpan, INSERM, U326, IFR 30, F-31059 Toulouse, France Hop Purpan IFR 30 Toulouse France F-31059 9 Toulouse, France
Citazione:
K. Missy et al., "Integrins and signal transduction: illustration with the alpha(IIb)beta(3)integrin in platelets", M S-MED SCI, 17(2), 2001, pp. 155-161

Abstract

The platelet specific integrin, alpha (IIb)beta (3), is largely prominent amongst the adhesion receptors (80000 copies per platelet) and is essentialfor platelet aggregation. In resting platelets, alpha (IIb)beta (3) is normally in a low activation state, unable to interact with soluble fibrinogen. Stimulation of platelets with various agonists will Induce a conformational change of alpha (IIb)beta (3) ("inside-out signalling") is then able to bind soluble fibrinogen resulting in the onset of platelet aggregation. A complex signaling pathway triggered by integrin ligation and clustering ("outside-in signalling") will regulate the extent of irreversible platelet aggregation and clot retraction. Amongst the signalling enzymes activated downstream of alpha (IIb)beta (3) engagement, a phosphoinositide 3-kinase playsimportant role in the control of the irreversible phase of aggregation. Its product, PtSIns(3,4)P-2, appears as a central player in a positive feed-back loop. Indeed, a certain level of integrin engagement is required for its production and, in turn, this lipid influences the strengthening and the irreversibility of aggregation through the stabilisation of the acto-myosincomplexes. The metabolic pathways leading to the integrin-dependent accumulation of PtdIns(3,4)P-2 and the alpha (IIb)beta (3) associated proteins that may regulate the irreversibility platelet aggregation are also discussedin this review.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 16:05:02