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Titolo:
Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory
Autore:
Duffy, SN; Craddock, KJ; Abel, T; Nguyen, PV;
Indirizzi:
Univ Alberta, Sch Med, Dept Physiol, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 iol, Edmonton, AB T6G 2H7, Canada Univ Alberta, Sch Med, Div Neurosci, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 sci, Edmonton, AB T6G 2H7, Canada Univ Penn, Dept Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dept Biol, Philadelphia, PA 19104 USA
Titolo Testata:
LEARNING & MEMORY
fascicolo: 1, volume: 8, anno: 2001,
pagine: 26 - 34
SICI:
1072-0502(200101/02)8:1<26:EEMTPO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PROTEIN-KINASE-C; LATE-PHASE; SYNAPTIC TRANSMISSION; RAT HIPPOCAMPUS; SPATIAL MEMORY; VISUAL-CORTEX; CYCLIC-AMP; COMPLEX ENVIRONMENTS; CYCLASE ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Nguyen, PV Univ Alberta, Sch Med, Dept Physiol, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 on, AB T6G 2H7, Canada
Citazione:
S.N. Duffy et al., "Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory", LEARN MEM, 8(1), 2001, pp. 26-34

Abstract

cAMP-dependent protein kinase (PKA) is critical for the expression of someforms of long-term potentiation (LTP) in area CA1 of the mouse hippocampusand for hippocampus-dependent memory. Exposure to spatially enriched environments can modify LTP and improve behavioral memory in rodents, but the molecular bases for the enhanced memory performance seen in enriched animals are undefined. We tested the hypothesis that exposure to a spatially enriched environment may alter the PKA dependence of hippocampal LTP. Hippocampalslices from enriched mice showed enhanced LTP following a single burst of 100-Hz stimulation in the Schaffer collateral pathway of area CA1. In slices from nonenriched mice, this single-burst form of LTP was less robust and was unaffected by Rp-cAMPS, an inhibitor of PKA. In contrast, the enhanced LTP in enriched mice was attenuated by Rp-cAMPS. Enriched slices expressed greater forskolin-induced, cAMP-dependent synaptic facilitation than did slices from nonenriched mice. Enriched mice showed improved memory for contextual fear conditioning, whereas memory for cued fear conditioning was unaffected following enrichment. Our data indicate that exposure of mice to spatial enrichment alters the PKA dependence of LTP and enhances one type of hippocampus-dependent memory. Environmental enrichment can transform the pharmacological profile of hippocampal LTP, possibly b) altering the threshold for activity-dependent recruitment of the cAMP-PKA signaling pathway following electrical and chemical stimulation. We suggest that experience-dependent plasticity of the PKA dependence of hippocampal LTP may be important forregulating the efficacy of hippocampus-based memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:35:39