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Titolo:
Effects of pharmacologically induced changes in NMDA-receptor activity on long-term memory in humans
Autore:
Rammsayer, TH;
Indirizzi:
Univ Gottingen, Georg Elias Mueller Inst Psychol, D-37073 Gottingen, Germany Univ Gottingen Gottingen Germany D-37073 hol, D-37073 Gottingen, Germany
Titolo Testata:
LEARNING & MEMORY
fascicolo: 1, volume: 8, anno: 2001,
pagine: 20 - 25
SICI:
1072-0502(200101/02)8:1<20:EOPICI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIRHINAL CORTEX ABLATION; OBJECT RECOGNITION MEMORY; NEUROTOXIC LESIONS; FORNIX TRANSECTION; FACE RECOGNITION; RHESUS-MONKEYS; GLUTAMATE; KETAMINE; RAT; PROSOPAGNOSIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Rammsayer, TH Univ Gottingen, Georg Elias Mueller Inst Psychol, D-37073 Gottingen, Germany Univ Gottingen Gottingen Germany D-37073 ottingen, Germany
Citazione:
T.H. Rammsayer, "Effects of pharmacologically induced changes in NMDA-receptor activity on long-term memory in humans", LEARN MEM, 8(1), 2001, pp. 20-25

Abstract

In a double-blind crossover design, either 30 mg of the noncompetitive NMDA-receptor antagonist memantine or a placebo was administered to 40 healthymale volunteers. Twenty line drawings of objects and 20 photographs of unfamiliar faces were presented on a computer screen. After a retention interval of 80 min, the participants' task was to select the original objects andfaces from a set of 80 items. Results were analyzed applying a signal-detection-theory approach. Recognition performance for objects was significantly impaired under memantine as compared to placebo, whereas performance on face recognition was not affected. Findings support the notion of differential effects of NMDA-receptor antagonists on memory functions in humans.

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Documento generato il 18/02/20 alle ore 05:26:19