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Titolo:
Nitric oxide, peroxynitrite and cGMP in atherosclerosis-induced hypertension in rabbits: Beneficial effects of cicletanine
Autore:
Szilvassy, Z; Csont, T; Pali, T; Droy-Lefaix, MT; Ferdinandy, P;
Indirizzi:
Univ Szeged, Dept Biochem, Cardiovasc Res Grp, H-6720 Szeged, Hungary UnivSzeged Szeged Hungary H-6720 iovasc Res Grp, H-6720 Szeged, Hungary Univ Debrecen, Dept Pharmacol, Debrecen, Hungary Univ Debrecen Debrecen Hungary recen, Dept Pharmacol, Debrecen, Hungary Biol Res Ctr, Dept Biophys, H-6701 Szeged, Hungary Biol Res Ctr Szeged Hungary H-6701 Dept Biophys, H-6701 Szeged, Hungary IPSEN Beaufour, Paris, France IPSEN Beaufour Paris FranceIPSEN Beaufour, Paris, France
Titolo Testata:
JOURNAL OF VASCULAR RESEARCH
fascicolo: 1, volume: 38, anno: 2001,
pagine: 39 - 46
SICI:
1018-1172(200101/02)38:1<39:NOPACI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; WORKING RAT HEARTS; POTASSIUM CHANNELS; GUANYLATE-CYCLASE; CONSCIOUS RABBITS; HYPERCHOLESTEROLEMIA; ENDOTHELIUM; SUPEROXIDE; CONTRIBUTES; PHOSPHODIESTERASES;
Keywords:
nitric oxide; cGMP; peroxynitrite; cicletanine; furosemide; atherosclerosis; cholesterol diet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Ferdinandy, P Univ Szeged, Dept Biochem, Cardiovasc Res Grp, Dom Ter 9, H-6720 Szeged, Hungary Univ Szeged Dom Ter 9 Szeged Hungary H-6720 Szeged, Hungary
Citazione:
Z. Szilvassy et al., "Nitric oxide, peroxynitrite and cGMP in atherosclerosis-induced hypertension in rabbits: Beneficial effects of cicletanine", J VASC RES, 38(1), 2001, pp. 39-46

Abstract

We studied the effect of the furopyridine derivative antihypertensive drug, cicletanine, on blood pressure, vascular nitric oxide (NO) and cyclic guanosine 3':5'-monophosphate (cGMP) content in the aorta and the renal and carotid arteries, aortic superoxide production, and serum nitrotyrosine levelin hypertensive/atherosclerotic rabbits. The effect of cicletanine was compared to that of furosemide. Rabbits were fed a normal or a cholesterol-enriched (1.5%) diet over 8 weeks. On the 8th week, the rabbits were treated per os with 2 x 50 mg/kg daily doses of cicletanine, furosemide, or vehicle for 5 days (n = 5-6 in each groups). The cholesterol diet increased mean arterial blood pressure (MABP) from 86 +/- 1 to 94 +/- 2 mm Hg (p < 0.05). Cicletanine decreased MABP in atherosclerotic rabbits to 85 +/- 1 mm Hg (p < 0.05), but it did not affect MABP in normal animals. Furosemide was withouteffect in both groups. In normal animals, NO content (assessed by electronspin resonance after in vivo spin trapping) in the aorta and the renal andcarotid arteries was increased by cicletanine, and the drug increased cGMPin the renal artery as measured by radioimmunoassay. The cholesterol-enriched diet decreased both vascular NO and cGMP and increased aortic superoxide production assessed by lucigenin-enhanced chemiluminescence and serum nitrotyrosine determined by ELISA. In atherosclerotic animals, cicletanine increased NO and cGMP content in the aorta and the renal and carotid arteries and decreased aortic superoxide production and serum nitrotyrosine. Furosemide did not influence these parameters. We conclude that cicletanine lowersblood pressure in hypertensive/atherosclerotic rabbits. The antihypertensive effect of the drug in atherosclerosis may be based on its beneficial effects on the vascular NO-cGMP system and on the formation of reactive oxygenspecies. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:27:45