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Titolo:
Sarcomas metastatic to the liver: Response and survival after cisplatin, doxorubicin, mitomycin-C, ethiodol, and polyvinyl alcohol chemoembolization
Autore:
Rajan, DK; Soulen, MC; Clark, TWI; Baum, RA; Haskal, ZJ; Shlansky-Goldberg, RD; Freiman, DB;
Indirizzi:
Hosp Univ Penn, Dept Radiol, Div Intervent Radiol, Philadelphia, PA 19104 USA Hosp Univ Penn Philadelphia PA USA 19104 diol, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 187 - 193
SICI:
1051-0443(200102)12:2<187:SMTTLR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCATHETER OILY CHEMOEMBOLIZATION; SMOOTH-MUSCLE TUMORS; SOFT-TISSUE SARCOMA; HEPATOCELLULAR-CARCINOMA; ARTERIAL EMBOLIZATION; GASTROINTESTINAL LEIOMYOSARCOMA; HEPATIC CHEMOEMBOLIZATION; PROGNOSTIC FACTORS; COMPLICATIONS; REGRESSION;
Keywords:
hepatic arteries, chemotherapeutic infusion chemotherapeutic infusion; sarcoma; chemoembolization; liver neoplasms, secondary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Soulen, MC Hosp Univ Penn, Dept Radiol, Div Intervent Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA Hosp Univ Penn 3400 Spruce St Philadelphia PA USA 19104 104 USA
Citazione:
D.K. Rajan et al., "Sarcomas metastatic to the liver: Response and survival after cisplatin, doxorubicin, mitomycin-C, ethiodol, and polyvinyl alcohol chemoembolization", J VAS INT R, 12(2), 2001, pp. 187-193

Abstract

PURPOSE: To evaluate the response to and survival after chemoembolization with cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol for patients with sarcomas metastatic to the liver that are surgically unresectable. MATERIALS AND METHODS: Sixteen patients were treated. Primary tumors included 11 gastrointestinal leiomyosarcomas, two splenic angiosarcomas, one leiomyosarcoma of the broad ligament, one leiomyosarcoma of the inferior vena cava, and one malignant fibrous histiocytoma of the colon. Chemoembolization with cisplatin, doxorubicin, mitomycin-C Ethiodol, and polyvinyl alcohol particles was performed 1-5 times at approximately monthly intervals (mean,2.8). Pre- and posttreatment cross-sectional imaging was performed 1 monthafter completion of treatment and then every 3 months. Thirty-day responsewas graded according to World Health Organization/Eastern Cooperative Oncology Group criteria. Survival was calculated with use of Kaplan-Meier analysis. RESULTS: Two patients (13%) exhibited partial morphologic response, 11 patients (69%) were morphologically stable, and three (19%) demonstrated progression of disease 30 days after completion of treatment. Among the 13 responders, two underwent partial hepatectomy after initial treatment. Seven developed intrahepatic progression at a mean of 10 months and a median time of8 months. The remaining four patients had no documented intrahepatic progression at the time of last imaging follow-up. Nine patients developed extrahepatic progression at a mean time of 6.3 months and a median time of 6 months, of whom four underwent additional surgical resection. Response to therapy was based on time of first intervention. Cumulative survival from time of diagnosis with use of Kaplan-Meier analysis was 81% at 1 year, 54% at 2 years, and 40% at 3 years. Median survival time was 20 months. Cumulative survival from initial chemoembolization was 67% at 1 year, 50% at 2 years, and 40% at 3 years, with a median survival time of 13 months. The thirty-daymortality rate was zero. CONCLUSION: Durable tumor response with chemoembolization is possible in this form of metastatic disease, which is highly resistant to systemic chemotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:12:56