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Titolo:
Guar gum reduces postprandial hypotension in older people
Autore:
Jones, KL; MacIntosh, C; Su, YC; Wells, F; Chapman, IM; Tonkin, A; Horowitz, M;
Indirizzi:
Univ Adelaide, Royal Adelaide Hosp, Dept Med, Adelaide, SA 5000, AustraliaUniv Adelaide Adelaide SA Australia 5000 ed, Adelaide, SA 5000, Australia Univ Adelaide, Royal Adelaide Hosp, Dept Clin Pharmacol, Adelaide, SA 5000, Australia Univ Adelaide Adelaide SA Australia 5000 ol, Adelaide, SA 5000, Australia
Titolo Testata:
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
fascicolo: 2, volume: 49, anno: 2001,
pagine: 162 - 167
SICI:
0002-8614(200102)49:2<162:GGRPHI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; ORAL GLUCOSE-TOLERANCE; BLOOD-PRESSURE; INSULIN RESPONSES; ELDERLY SUBJECTS; MANAGEMENT; HUNGER; SOMATOSTATIN; ABSORPTION; MECHANISMS;
Keywords:
postprandial hypotension; gastric emptying; small intestinal absorption; 3-OMG; older; blood glucose; guar gum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, KL Univ Adelaide, Royal Adelaide Hosp, Dept Med, North Terrace, Adelaide, SA 5000, Australia Univ Adelaide North Terrace Adelaide SA Australia5000 Australia
Citazione:
K.L. Jones et al., "Guar gum reduces postprandial hypotension in older people", J AM GER SO, 49(2), 2001, pp. 162-167

Abstract

OBJECTIVE: To determine whether slowing of gastric emptying and glucose absorption with guar gum would reduce the fall in blood pressure after an oral glucose load in older subjects. DESIGN: A randomized, experimental, cross-over study. SETTING: Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia. PARTICIPANTS: Ten healthy subjects, age 67 to 78. MEASUREMENTS: Simultaneous measurements of gastric emptying, blood pressure, blood glucose, serum insulin, and oral glucose absorption (3-O-methyl-D-glucose [3-OMG]) on two occasions after ingestion of 300 mL water containing 50 g glucose and 30 mL lemon juice, 3 g 3-OMG labeled with Tc-99m-sulphurcolloid; with or without 9 g guar gum. Blood pressure and gastric emptyingwere monitored for 180 minutes. RESULTS: The magnitude of the falls in systolic (P = .02), diastolic (P < .05), and mean arterial (P = .05) blood pressure were less, and gastric emptying slower (P < .05), after guar. Blood glucose, insulin, and 3-OMG concentrations were reduced (P < .001 for all) by guar. 3-OMG con centrations were inversely related to the intragastric retention of glucose (r = -0.72, P= .02) and blood pressure was inversely related to 3-OMG (r = -0.64, P < .05) after the drink without guar. The blood glucose concentration was related to 3-OMG (r > 0.64, P < .05). CONCLUSION: Guar gum reduces the magnitude of the fall in blood pressure after oral glucose. Slowing of gastric emptying and glucose absorption may represent a novel approach to the treatment of postprandial hypotension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:54:44