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Titolo:
Effects of diazepam on neutrophil (PMN) free amino acid profiles and immune functions in vitro. Metabolical and immunological consequences of L-alanyl-L-glutamine supplementation
Autore:
Muhling, J; Sablotzki, A; Fuchs, M; Krull, M; Dehne, MG; Weiss, S; Gonter, J; Quandt, D; Hempelmann, G;
Indirizzi:
Univ Giessen, Dept Anaesthesiol & Intens Care Med, Giessen, Germany Univ Giessen Giessen Germany hesiol & Intens Care Med, Giessen, Germany Univ Halle Wittenberg, Clin Anaesthesiol, Halle, Germany Univ Halle Wittenberg Halle Germany , Clin Anaesthesiol, Halle, Germany Univ Halle Wittenberg, Clin Intens Care Med, Halle, Germany Univ Halle Wittenberg Halle Germany lin Intens Care Med, Halle, Germany Dr Ing Herbert Knauer GmbH, Berlin, Germany Dr Ing Herbert Knauer GmbH Berlin Germany Knauer GmbH, Berlin, Germany Humboldt Univ, Sch Med, Dept Internal Med Infect Dis, Charite, Berlin, Germany Humboldt Univ Berlin Germany l Med Infect Dis, Charite, Berlin, Germany
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 46 - 54
SICI:
0955-2863(200101)12:1<46:EODON(>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; TOTAL PARENTERAL-NUTRITION; CELL-VOLUME; L-ARGININE; IN-VITRO; CONTAINING DIPEPTIDES; INTESTINAL FUNCTION; HUMAN MONOCYTES; TAURINE EFFLUX; MACROPHAGES;
Keywords:
diazepam; L-alanyl-L-glutamine; neutrophils; amino acids; immune function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Muhling, J Univ Giessen, Dept Anaesthesiol & Intens Care Med, Giessen, Germany Univ Giessen Giessen Germany tens Care Med, Giessen, Germany
Citazione:
J. Muhling et al., "Effects of diazepam on neutrophil (PMN) free amino acid profiles and immune functions in vitro. Metabolical and immunological consequences of L-alanyl-L-glutamine supplementation", J NUTR BIOC, 12(1), 2001, pp. 46-54

Abstract

The objective of this study was to determine the effects of diazepam, L-alanyl-L-glutamine (ala-gln) or diazepam combined with ala-gln on polymorphonuclear leukocyte (PMN) free amino acid profiles. In a parallel study the effects on PMN immune functions were also documented for the first time. The incubation of whole blood with diazepam led to significant changes in PMN free glutamine, aspartate, glutamate, ornithine, arginine, citrulline, taurine and methionine as well as branched chain and neutral amino acid concentrations. Ala-gln caused significant increases in PMN glutamine and alanine and asparagine, aspartate, glutamate, ornithine, arginine, serine and glycine profiles. Regarding PMN immune functions, diazepam significantly decreased superoxide anion (O-2(-)) and hydrogen peroxide production (H2O2) and myeloperoxidase activity (MPO) while ala-gln significantly increased PMN immune functions. Ala-gln supplemented to diazepam largely reversed the changes in PMN amino acid profiles and PMN immune functions brought about by diazepam. Overall, diazepam or ale-gin lead to significant changes in PMN free amino acids. Important PMN immune functions also seem to be affected. In regards to the results, there is significant relevance to the pharmacological regimens which enhance the supply of diazepam or ala-gln in whole blood suggesting that considerable changes in PMN "labile free amino acid pool" occur. These regimens often follow beneficial nutritional therapy or maleficent pharmacological stress and may be one of the determinants in cell nutritionwhich influence PMN function. It is partially through its effect on PMN labile free amino acid pool that ala-gln supplemented to diazepam may maintain PMN immune functions in vitro. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:52:27