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Titolo:
Influence of dietary partially hydrogenated fat high in trans fatty acids on lipid composition and function of intestinal brush border membrane in rats
Autore:
Ibrahim, SA; Ghafoorunissa;
Indirizzi:
Indian Council Med Res, Natl Inst Nutr, Hyderabad 500007, Andhra Pradesh, India Indian Council Med Res Hyderabad Andhra Pradesh India 500007 adesh, India
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 116 - 120
SICI:
0955-2863(200102)12:2<116:IODPHF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKALINE-PHOSPHATASE ACTIVITY; MICROVILLUS MEMBRANES; LINOLEIC-ACID; PLASMA-MEMBRANES; D-GLUCOSE; FLUIDITY; BIOSYNTHESIS; METABOLISM; RECEPTORS; SYSTEMS;
Keywords:
intestine; brush border membrane; trans fatty acids; lipid composition; membrane function; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ghafoorunissa Indian Council Med Res, Natl Inst Nutr, Jamai Osmania PO, Hyderabad 500007, Andhra Pradesh, India Indian Council Med Res Jamai Osmania PO Hyderabad Andhra Pradesh India 500007
Citazione:
S.A. Ibrahim e Ghafoorunissa, "Influence of dietary partially hydrogenated fat high in trans fatty acids on lipid composition and function of intestinal brush border membrane in rats", J NUTR BIOC, 12(2), 2001, pp. 116-120

Abstract

The effect of dietary hydrogenated fat (Indian vanaspati) high in trans fatty acids (6 en%) on lipid composition, fluidity and function of rat intestinal brush border membrane was studied at 2 and 8 en% of linoleic acid. Three groups of weanling rats were fed rice-pulse based diet containing 10% fat over a ten week period: Group I (groundnut oil), Group II (vanaspati), Group III (vanaspati + safflower oil). The functionality of the brush border membrane was assessed by the activity of membrane bound enzymes and transport of D-glucose and L-leucine. The levels of total cholesterol and phospholipids were similar in all groups. The data on fatty acid composition of membrane phospholipids showed that, at 2 en% of linoleic acid in the diet, trans fatty acids lowered arachidonic acid and increased linoleic acid contents indicating altered polyunsaturated fatty acid metabolism. Alkaline phosphatase activity was increased while the activities of sucrase, gamma -glutamyl transpeptidase and transport of D-glucose and L-leucine were not alteredby dietary trans fatty acids. However at higher intake of linoleic acid inthe diet, trans fatty acids have no effect on polyunsaturated fatty acid composition and alkaline phosphatase activity of intestinal brush border membrane. These data suggest that feeding dietary fat high in trans fatty acids is associated with alteration in intestinal brush border membrane polyunsaturated fatty acid composition and alkaline phosphatase activity only whenthe dietary linoleic acid is low. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 01:03:33