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Titolo:
Dietary taurine potentiates polychlorinated biphenyl-induced hypercholesterolemia in rats
Autore:
Mochizuki, H; Oda, H; Yokogoshi, H;
Indirizzi:
Univ Shizuoka, Sch Food & Nutr Sci, Shizuoka, Japan Univ Shizuoka Shizuoka Japan uoka, Sch Food & Nutr Sci, Shizuoka, Japan Nagoya Univ, Dept Appl Mol Biosci, Nagoya, Aichi, Japan Nagoya Univ Nagoya Aichi Japan ept Appl Mol Biosci, Nagoya, Aichi, Japan
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 109 - 115
SICI:
0955-2863(200102)12:2<109:DTPPBH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-I; HIGH-DENSITY-LIPOPROTEIN; URINARY ASCORBIC-ACID; HIGH-CHOLESTEROL DIET; GENE-EXPRESSION; FED PCB; LIVER; SERUM; METABOLISM; METHIONINE;
Keywords:
taurine; polychlorinated biphenyls; cholesterol; hypercholesterolemia; HDL; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Yokogoshi, H Univ Shizuoka, Sch Food & Nutr Sci, Shizuoka, Japan Univ Shizuoka Shizuoka Japan d & Nutr Sci, Shizuoka, Japan
Citazione:
H. Mochizuki et al., "Dietary taurine potentiates polychlorinated biphenyl-induced hypercholesterolemia in rats", J NUTR BIOC, 12(2), 2001, pp. 109-115

Abstract

The effect of dietary taurine on cholesterol metabolism and the distribution of lipoprotein-cholesterol in serum of rats fed a diet containing polychlorinated biphenyls (PCB) was examined. Young male Wistar rats (60 g) were fed diets containing 0.2 g/kg diet of PCB and/or 30 g/kg diet of taurine for 15 days. The experiment was performed as the 2 (PCB) X 2 (taurine) factorial design. The addition of PCB elevated serum levels of total- and HDL-cholesterol and apolipoprotein A-I, which is a major apolipoprotein of HDL. Simultaneous supplementation of taurine with PCB amplified the increase of the serum level of total- and HDL-cholesterol. Hepatic concentrations of cholesterol and total lipids were significantly elevated by the supplementationof PCB, and taurine significantly amplified these increases caused by PCB. PCB suppressed hepatic cholesterol 7 alpha -hydroxylase (CYP7A1) gene expression, and taurine induced CYP7A1 gene expression. Taurine also enhanced PCB-induced elevation of malic enzyme mRNA in the liver. These results suggest that taurine enhanced PCB-induced hyper-a-cholesterolemia and that taurine has a role in increasing HDL-cholesterol. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:36:53